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Another brick in the wall: is hexane neuropathy a ‘nodo-paranodopathy’?

  • Sezin Alpaydin BasloEmail author
  • Oya Ozturk
  • Cengiz Dayan
  • Dilek Atakli
  • Mehmet Baris Baslo
Original article
  • 15 Downloads

Abstract

n-Hexane gives cause to one of the most common toxic polyneuropathies seen in poorly ventilated factories. It is a sensory-motor polyneuropathy ending up with axonal degeneration. Nerve biopsy reveals paranodal axonal swelling and secondary myelin retraction in early stages. Myelin retraction imitates demyelination causing focal conduction block and failure before axonal degeneration emerges. This brings to mind the new category of nodo-paranodopathy described first for anti-ganglioside antibody-mediated neuropathies, which can be proved by electrophysiological re-evaluations. We, herein, discuss the clinical and electrophysiological follow-up of three patients with n-hexane neuropathy and remark overlaps with new concept nodo-paranodopathy.

Keywords

n-Hexane Toxic neuropathy Nodo-paranodopathy Conduction block Polyneuropathy 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Belgian Neurological Society 2019

Authors and Affiliations

  1. 1.Department of Neurology, Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric, Neurologic, and Neurosurgical DiseasesUniversity of Health SciencesBakırköyTurkey
  2. 2.Department of Neurology, Istanbul Medical FacultyIstanbul UniversityIstanbulTurkey

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