Acta Neurologica Belgica

, Volume 119, Issue 4, pp 637–639 | Cite as

Limbic encephalitis-like presentation in neuromyelitis optica spectrum disorder: a case report

  • Jin Myoung Seok
  • Hye Jeong Oh
  • Seung Cheol Lee
  • Min Su ParkEmail author
Letter to the Editor


Limbic encephalitis is a syndrome characterized by memory loss, psychiatric symptoms and convulsion, and typical brain lesions are located in mesial temporal lobe. Once known almost always associated with cancer, limbic encephalitis is now considered as a clinical syndrome of autoimmune encephalitis despite whether cancer related or not [1].

Neuromyelitis optica (NMO) is a rare idiopathic inflammatory disorder of the central nervous system (CNS) with the predominant involvement of the optic nerves and spinal cord having disease-specific autoantibody against aquaporin-4 protein (AQP4-Ab). Various brain syndromes with distinctive brain lesions in patients with NMO have been reported that area of postrema syndrome, acute brainstem syndrome, acute narcolepsy/diencephalic syndrome and symptomatic cerebral syndrome were studied with brain MRI findings [2]. However, limbic encephalitis syndrome and the medial temporal lobe lesions have never been reported in NMOSD. We herein...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

The informed consent was obtained from the patient.

Supplementary material

13760_2019_1114_MOESM1_ESM.jpg (585 kb)
Supplementary material 1 (JPG 584 KB)


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Copyright information

© Belgian Neurological Society 2019

Authors and Affiliations

  • Jin Myoung Seok
    • 1
  • Hye Jeong Oh
    • 1
  • Seung Cheol Lee
    • 1
  • Min Su Park
    • 2
    Email author
  1. 1.Department of Neurology, Soonchunhyang University Cheonan Hospital, College of MedicineSoonchunhyang UniversityCheonanSouth Korea
  2. 2.Department of NeurologyYeungnam University College of MedicineDaeguSouth Korea

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