Acta Neurologica Belgica

, Volume 119, Issue 4, pp 549–553 | Cite as

Clinical use of 99mTc-HMPAO-labeled platelets in cerebral sinus thrombosis imaging

  • Abbas Tafakhori
  • Mahdieh Parvizi
  • Saeed Farzanefar
  • Hojjat Ahmadzadehfar
  • Ali Khalaj
  • Maryam Naseri
  • Mehrshad AbbasiEmail author
Original article


Magnetic resonance imaging (MRI) and computed tomography (CT) are not always conclusive for the detection of cerebral venous sinus thrombosis (CVST). 99mTc-HMPAO-labeled platelets may be useful in cases with high clinical suspicion. Three patients with headaches with or without intraparenchymal hemorrhage that were highly suspected to have CVST, despite inconclusive anatomical imaging, were selected for inclusion in the study. Platelets were extracted by two rounds of centrifugation from 49 ml of the patient’s whole blood. The platelets were labeled with 99mTc-HMPAO and any unbound 99mTc was removed by centrifugation. The re-suspension of 99mTc-HMPAO-labeled platelets in cell-free plasma was reinjected into the patients. After 2 h, planar and single photon emission computed tomography (SPECT) images of the head were obtained. Extensive clots were detected in all three patients, illustrated in the planar image and even clearer in the SPECT images. We propose that 99mTc-HMPAO-labeled platelet scan is a favorable imaging method for patients suspected to have CVST with inconclusive CT and MRI results.


99mTc-HMPAO-labeled platelets scan Intraparenchymal hemorrhage Headache Clot 



The research was done as a part of the Ph.D. thesis of Tehran University of Medical Sciences.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Belgian Neurological Society 2019

Authors and Affiliations

  1. 1.Department of Neurology, School of Medicine, Imam Khomeini HospitalTehran University of Medical SciencesTehranIran
  2. 2.Department of Radiopharmacy, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  3. 3.Department of Nuclear Medicine, Vali-Asr HospitalTehran University of Medical SciencesTehranIran
  4. 4.Department of Nuclear MedicineUniversity Hospital BonnBonnGermany
  5. 5.Department of Medicinal Chemistry, Faculty of PharmacyTehran University of Medical SciencesTehranIran

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