Injury of the prefronto-caudate tract in a patient with apathy following intracerebral hemorrhage in the caudate nucleus
The caudate nucleus (CN), as a part of the basal ganglia, interconnects with the prefrontal cortex (PFC), temporal cortex, frontal eye field, and cerebellum. These connections are involved in motor and cognitive functions . Specifically, the prefronto-caudate tract is involved in apathy, anxiety, depression, and disinhibition . Apathy is classically defined as a lack of feeling, emotion, interest and concern, and clinically presents as the absence of motivation, voluntary movement or speech . Injury of the CN, PFC, or the prefronto-caudate tract in particular, connected to the medial PFC, and orbitofrontal cortex (OFC) is related to apathy [4, 5].
Diffusion tensor tractography (DTT), a three-dimensional imaging tool, is based on diffusion tensor imaging (DTI). This technique measures characteristics of water diffusion in brain tissue, allowing assessment of the state of neural connectivity . Probabilistic DTT, that reflects the distribution of underlying fiber...
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. 2018R1A2B6000996).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The authors declare that they acted in accordance with ethical standards laid down in the 1964 Declaration of Helsinki.
Informed consent was obtained from all individual participants included in the study.
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