Acta Neurologica Belgica

, Volume 119, Issue 1, pp 141–142 | Cite as

Methotrexate-induced pseudotumor cerebri in a patient with juvenile idiopathic arthritis

  • Faruk IncecikEmail author
  • Duygu G. Ozcanyuz
  • Mustafa Yılmaz
Letter to the Editor


Pseudotumor cerebri (PTC) is a rare neurological disorder characterized by increased intracranial pressure in the absence of any intracranial space-occupying lesion. PTC may be primary or occur secondary to certain conditions. In secondary cases, some conditions including certain medications, endocrine abnormalities, autoimmune disorders, anemias, infectious or postinfectious processes, and cranial venous outflow abnormalities have been identified as causative agents [1].

Methotrexate (MTX) is one of the most effective and widely used medications for treating juvenile idiopathic arthritis (JIA) and other inflammatory types of arthritis [2]. However, MTX may result in adverse effects including hepatic, pulmonary, and renal toxicity as well as lymphoproliferative disorders and predisposition to infection [2, 3]. There has been only one report of PTC in association with MTX in an adult patient in the literature [4]. We report a case of PTC in a patient with JIA due to MTX...



This case report was not funded.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained.


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Copyright information

© Belgian Neurological Society 2018

Authors and Affiliations

  • Faruk Incecik
    • 1
    Email author
  • Duygu G. Ozcanyuz
    • 1
  • Mustafa Yılmaz
    • 1
    • 2
  1. 1.Division of Pediatric NeurologyCukurova University Faculty of MedicineAdanaTurkey
  2. 2.Division of Pediatric RheumatologyCukurova University Faculty of MedicineAdanaTurkey

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