Sudden blindness and deafness disclosing meningeal carcinomatosis in non-small cell lung cancer

  • Guillaume CostentinEmail author
  • C. Richard
  • A. Rouille
  • B. Bourre
  • R. Lefaucheur
  • L. Grangeon
Letter to the Editor

Case report

A 63-year-old woman was admitted for acute right-sided hearing loss and acute dizziness, initially diagnosed as vestibular neuritis. She had no medical history except active smoking. Neurological examination was normal. Hearing loss progressively worsened over the week after, becoming bilateral and leading to complete deafness. Repeated clinical examination showed a right peripheral facial palsy and pyramidal syndrome with bilateral Babinski’s sign. She had no fever and was not confused. There were no B-symptoms or respiratory complaints. Blood cell count and C-reactive protein were normal. Brain CT scan was normal. CSF analysis disclosed 38 leukocytes/µL (N < 5 leukocytes/µL), 400 red blood cells/µL (N < 5/µL), a protein level of 1.0 g/L (N < 0.40 g/L), and a glucose level of 0.4 g/L (N = 0.5–0.8 g/L). Cytology analysis identified malignant cells with positive TTF1 and CK7 immunostaining, which strongly supported the diagnosis of meningeal carcinomatosis (MC) associated...


Meningeal carcinomatosis Blindness Deafness Non-small cell lung cancer 


Author contributions

GC: acquisition of data, analysis, interpretation, critical revision of the manuscript for important intellectual content, and study supervision. CR: acquisition of data, analysis, and interpretation. AR: acquisition of data, analysis, and interpretation. BB: acquisition of data, analysis, and interpretation. RL: acquisition of data, analysis, interpretation, and critical revision of the manuscript for important intellectual content. LG: acquisition of data, analysis, interpretation, and critical revision of the manuscript for important intellectual content.


No funding was received.

Compliance with ethical standards

Conflict of interest

Guillaume Costentin reports no financial disclosures. Clément Richard reports no financial disclosures. Audrey Rouillé reports no financial disclosures. Bertrand Bourre reports no financial disclosures. Romain Lefaucheur reports no financial disclosures. Lou Grangeon reports no financial disclosures.

Research involving human and animals participants

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© Belgian Neurological Society 2018

Authors and Affiliations

  1. 1.Department of NeurologyRouen University HospitalRouen CedexFrance

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