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Can We Talk About Feminist Epistemic Values Beyond Gender? Lessons from the Gut Microbiome

Abstract

I examine the feminist epistemic values in science, presented by Helen Longino, and their role in framing microbiome causality in the study of inflammatory bowel disease (IBD). In particular, I show how values presented as feminist give an alternative view in scientific theories—focusing on ontological heterogeneity and mutuality of interactions rather than simplicity and one causal direction—when looking at relations between organisms and microorganisms, and between organisms (particularly humans) and their environment. I identify two approaches in microbiome study, an immunological approach that looks at the microbiome pathogenicity and an ecological approach that studies the microbial activity and functions. I show the puzzles stemming from the traditional background beliefs of the immune self and germ theory in the study of IBD causality. Furthermore, I argue for the benefits of a shift to the ecological view of body-microbe interrelations. I conclude with the benefits and advantages of feminist values over traditional ones, both in creating new ways of understanding organisms’ physiology and immune systems and for future biomedical studies involving microbiome causality.

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Notes

  1. 1.

    Elizabeth Anderson (2004) demonstrates this in her case study showing the bidirectional influence of facts and values. She presents the research on divorce done by Stewart et al. (1997), where the researchers explicitly state their background interest as well as their research questions. Doing so, they show how their background interest serves as the framework for pointing to the object of inquiry and for the decision of what types of data to collect (Anderson 2004).

  2. 2.

    This analysis is of scientific practices in general and not of specific cases of bad science where the evidence is rigged to match the hypothesis. Therefore, the chosen evidence, in accordance with the background beliefs of the scientists, can still refute the hypothesis.

  3. 3.

    For more information see the link to Elinav Lab: http://www.weizmann.ac.il/immunology/elinav/.

  4. 4.

    For more information see the link to Dutton Lab: https://sites.google.com/site/theduttonlab/.

  5. 5.

    I do not argue for the causality of the epistemic values. I argue that they are consistent with the background beliefs and that the relationship is of mutual influence. Thus, in this relationship, the feminist epistemic values are better in the ecological approach than the immunological regarding the causal explanation in IBD. I thank an anonymous reviewer for clarifying this distinction.

  6. 6.

    The dialectical approach in biology is consistent with some of the feminist heuristics, but it is nonfeminist in part because it does not give the same attention to relations of dominance. I thank the anonymous reviewer for emphasizing this point.

References

  1. Abraham C, Medzhitov R (2011) Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology 140(6):1729–1737. https://doi.org/10.1053/j.gastro.2011.02.012

  2. Anderson E (2004) Uses of value judgments in science: a general argument, with lessons from a case study of feminist research on divorce. Hypatia J Fem Philos 19(1):1–24

  3. Chiu L, Bazin T, Truchetet M-E, Schaeverbeke T, Delhaes L, Pradeu T (2017) Protective microbiota: from localized to long-reaching co-immunity. Front Immunol. https://doi.org/10.3389/fimmu.2017.01678

  4. Clough S (1998) A hasty retreat from evidence: the recalcitrance of relativism in feminist epistemology. Hypatia J Fem Philos 13(4):88–111. https://doi.org/10.1111/j.1527-2001.1998.tb01386.x

  5. Cohen IR (2000) Tending Adam’s garden. Academic Press, San Diego

  6. Corrêa-Oliveira R, Fachi JL, Vieira A, Sato FT, Vinolo MA (2016) Regulation of immune cell function by short-chain fatty acids. Clin Transl Immunol 5(4):e73. https://doi.org/10.1038/cti.2016.17

  7. de Lange KM, Barrett JC (2015) Understanding inflammatory bowel disease via immunogenetics. J Autoimmun 64:91–100. https://doi.org/10.1016/j.jaut.2015.07.013

  8. Douglas H (2009) Science, policy, and the value-free ideal. University of Pittsburgh Press, Pittsburgh

  9. Douglas H (2013) The value of cognitive values. Philos Sci 80(5):796–806

  10. Ek WE, D’Amato M, Halfvarson J (2014) The history of genetics in inflammatory bowel disease. Ann Gastroenterol 27(4):294–303

  11. Elliott K (2017) A tapestry of values: an introduction to values in science. Oxford University Press, New York

  12. Ferrer M, Méndez-García C, Rojo D, Barbas C, Moya A (2017) Antibiotic use and microbiome function. Biochem Pharmacol 134:114–126. https://doi.org/10.1016/j.bcp.2016.09.007

  13. Funkhouser L, Bordenstein S (2013) Mom knows best: the universality of maternal microbial transmission. PLoS Biol 11(8):e1001631. https://doi.org/10.1371/journal.pbio.1001631

  14. Gilbert S, Bosch T, Ledón-Rettig C (2015) Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents. Nat Rev Genet 16:611–622

  15. Intemann K (2005) Feminism, underdetermination, and values in science. Philos Sci 72:1001–1012. https://doi.org/10.1086/508956

  16. Kim CH (2018) Immune regulation by microbiome metabolites. Immunology 154:220–229. https://doi.org/10.1111/imm.12930

  17. Kuhn T (1977) Objectivity, value judgment, and theory choice. Reprint: The essential tension: selected studies in the scientific tradition and change. University of Chicago Press, Chicago, pp 223–262

  18. Levins R (1966) The strategy of modeling in population biology. Am Sci 54(4):421–431

  19. Longino HE (1979) Evidence and hypothesis. Philos Sci 46(1):35–56

  20. Longino HE (1983) Beyond ‘bad science’: skeptical reflections on science and values. Sci Technol Hum Values 8(1):7–17

  21. Longino HE (1996) Cognitive and non-cognitive values in science: rethinking the dichotomy. In: Nelson LH, Nelson J (eds) Feminism, science, and the philosophy of science. Kluwer Academic Publishers, Dordrecht, pp 39–58

  22. Longino HE, Lennon, K (1997) Feminist epistemology as a local epistemology. Proc Aristot Soc 71:19–35 + 37–54

  23. Longino HE (2008) Values, heuristics, and the politics of knowledge. In: Carrier M, Howard D, Kourany JA (eds) The challenge of the social and the pressure of practice, science and values revisited. University of Pittsburgh Press, Pittsburgh, pp 68–86

  24. Martin E (1991) The egg and the sperm: how science has constructed a romance based on stereotypical male-female roles. Signs 16(3):485–501

  25. McFall-Ngai M, Hadfield MG, Bosch TCG, Carey HV, Domazet-Lošo T, Douglas AE et al (2013) Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci USA 110:3229–3236. https://doi.org/10.1073/pnas.1218525110

  26. Moya A, Ferrer M (2016) Functional redundancy-induced stability of gut microbiota subjected to disturbance. Trends Microbiol 24(5):402–413. https://doi.org/10.1016/j.tim.2016.02.002

  27. Mushegian AA, Ebert D (2016) Rethinking “mutualism” in diverse host-symbiont communities. BioEssays 38:100–108. https://doi.org/10.1002/bies.201500074

  28. NIH National Institute of Diabetes and Digestive and Kidney Diseases (2019) Story of discovery: discoveries moving towards understanding and personalized treatment of inflammatory bowel disease. In: News archive, 16 Jan 2019. https://www.niddk.nih.gov/news/archive/2019/story-discovery-moving-towards-understanding-treatment-ibs. Accessed 7 Aug 2019

  29. Pradeu T (2012) The limits of the self: immunology and biological identity. Oxford University Press, Oxford

  30. Pradeu T, Carosella ED (2006) The self model and the conception of biological identity in immunology. Biol Philos 21:235–252. https://doi.org/10.1007/s10539-005-8621-6

  31. Pradeu T, Vivier E (2016) The discontinuity theory of immunity. Sci Immunol 1:aag0479. https://doi.org/10.1126/sciimmunol.aag0479

  32. Prescott SL (2017) History of medicine: origin of the term microbiome and why it matters. Hum Microbiome J 4:24–25. https://doi.org/10.1016/j.humic.2017.05.004

  33. Robinson CJ, Bohannan BJM, Young VB (2010) From structure to function: the ecology of host-associated microbial communities. Microbiol Mol Biol Rev 74(3):453–476. https://doi.org/10.1128/MMBR.00014-10

  34. Rooney P (1992) On values in science: is the epistemic/non-epistemic distinction useful? Proc Bienn Meet Philos Sci Assoc 1:13–22

  35. Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9:313–323. https://doi.org/10.1038/nri2515

  36. Rowland I, Gibson G, Heinken A, Scott K, Swann J, Thiele I, Tuohy K (2018) Gut microbiota functions: metabolism of nutrients and other food components. Eur J Nutr 57:1–24. https://doi.org/10.1007/s00394-017-1445-8

  37. Sapp J (1994) Evolution by association: a history of symbiosis. Oxford University Press, New York

  38. Sartor RB, Wu GD (2017) Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches. Gastroenterology 152:327–339.e4. https://doi.org/10.1053/j.gastro.2016.10.012

  39. Skillings D (2016) Holobionts and the ecology of organisms: multi-species communities or integrated individuals? Biol Philos. https://doi.org/10.1007/s10539-016-9544-0

  40. Steel D (2009) Epistemic values and the argument from inductive risk. Philos Sci 77:14–34. https://doi.org/10.1086/650206

  41. Steel D (2015) Philosophy and the precautionary principle. Cambridge University Press, Cambridge

  42. Stewart AJ, Copeland AP, Chester NL, Malley JE, Barenbaum NB (1997) Separating together: how divorce transforms families. Guilford Press, New York

  43. Swiatczak B, Rescigno M, Cohen I (2011) Systemic features of immune recognition in the gut. Microbes Infect 13(12–13):983–991. https://doi.org/10.1016/j.micinf.2011.06.011

  44. Tauber A (ed) (1991) Organism and the origin of self. Kluwer Academic Publishers, Boston, pp 1–39

  45. Tauber A (2004) Immunology and the enigma of selfhood. In: Wise MN (ed) Growing explanations: historical perspectives on recent science. Duke University Press, Durham, pp 202–221

  46. Turnbaugh PT, Ley RE, Hamady M, Fraser-Liggett C, Knight R, Gordon JI (2007) The human microbiome project: exploring the microbial part of ourselves in a changing world. Nature 449(7164):804–810. https://doi.org/10.1038/nature06244

  47. Wong SY, Cadwell K (2018) There was collusion: microbes in inflammatory bowel disease. PLoS Pathog 14(9):e1007215. https://doi.org/10.1371/journal.ppat.1007215

  48. Zeevi D, Korem T, Zmora N, Israeli D, Rothschild D, Weinberger A et al (2015) Personalized nutrition by prediction of glycemic responses. Cell 163(5):1079–1094. https://doi.org/10.1016/j.cell.2015.11.001

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Acknowledgements

Many thanks to Roberta Millstein and James Griesemer for their encouragement, guidance, and helpful comments on earlier drafts of this paper. Also, to Helen Longino for inspiring conversations and to the Griesemer/Millstein Philosophy of Biology Lab and the UC Davis Philosophy Department for thoughtful comments and discussions. Special thanks for Zachary Piso for his thoughtful comments on later drafts and to the anonymous reviewers.

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Correspondence to Tamar Schneider.

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Schneider, T. Can We Talk About Feminist Epistemic Values Beyond Gender? Lessons from the Gut Microbiome. Biol Theory 15, 25–38 (2020). https://doi.org/10.1007/s13752-019-00335-5

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Keywords

  • Epistemic values
  • Germ theory
  • Immune-self
  • Microbiome
  • Mutuality of interactions
  • Ontological heterogeneity