Magnetic nano-carbon core shell as potent mixed hemimicelle solid phase extraction strategy for determination of acrylamide from potato chips coupled by high-performance liquid chromatography

  • Arezou Taghvimi
  • Samin Hamidi
  • Yousef Javadzadeh
  • Siavoush Dastmalchi
  • Mahnaz TabibiazarEmail author
Original Paper


Magnetic nano-carbon core shell was applied as mixed hemimicelle magnetic solid phase extraction adsorbent to introduce a novel sample preparation method for determination of acrylamide from potato chips. Acrylamide is identified as neurotoxic, a probable human carcinogen (group 2A) compound. Effective extraction parameters such as type and amount of extracting solvent, type and amount of adsorbent, time of extraction and desorption, the effect of pH, time of ionic liquid loading on the adsorbent and stirring rate (rpm) were studied and optimized. Under optimized extraction conditions, a good linearity was observed in the concentration range of 100–1500 ng/g. Limit of detection was observed as 30 ng/g. Application of the proposed method was surveyed by analysis of some potato chips brands available in the local supermarkets. The satisfactory results with the recovery of 95.58% revealed that the proposed method could be applied in food analysis laboratories.


Magnetic solid phase extraction Mixed hemimicelle Magnetic nano-carbon core shell Potato chips Acrylamide HPLC–UV 



Magnetic nano-carbon


Liquid–liquid extraction


Magnetic nanoparticles




Solid phase micro-extraction


Ionic liquid


Magnetic solid phase extraction


Dispersive liquid–liquid micro-extraction


European food safety authority


Ionic liquid magnetic nano-carbon



The authors sincerely appreciate Biotechnology Research Centre and Faculty of Nutrition and Food Science of Tabriz University of Medical Sciences for supporting the project.


This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. Conflict of interest: All the authors declare that there is no conflict of interest.

Compliance with ethical standards

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Not applicable.


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Copyright information

© Iranian Chemical Society 2019

Authors and Affiliations

  • Arezou Taghvimi
    • 1
  • Samin Hamidi
    • 2
  • Yousef Javadzadeh
    • 3
    • 4
  • Siavoush Dastmalchi
    • 3
    • 4
  • Mahnaz Tabibiazar
    • 5
    Email author
  1. 1.Biotechnology Research Centre and Student Research CommitteeTabriz University of Medical ScienceTabrizIran
  2. 2.Food and Drug Safety Research CentreTabriz University of Medical ScienceTabrizIran
  3. 3.Biotechnology Research Center, Faculty of PharmacyTabriz University of Medical ScienceTabrizIran
  4. 4.Faculty of PharmacyNear East UniversityNicosia, Mersin 10Turkey
  5. 5.Drug Applied Research Center and Department of Food Science and Technology, Faculty of Nutrition and Food ScienceTabriz University of Medical ScienceTabrizIran

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