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Vitamin C as a green and robust catalyst for the fast and efficient synthesis of valuable organic compounds via multi-component reactions in water

  • Ahmad ShaabaniEmail author
  • Vida Khodkari
  • Mohammad Taghi Nazeri
  • Shima Ghasemi
  • Reza Mohammadian
  • Shabnam Shaabani
Original Paper
  • 11 Downloads

Abstract

In the present paper, we report l-ascorbic acid (vitamin C) as an efficient and robust catalyst for the straightforward synthesis of various organic compounds, including carboxamide, benzodiazepine and benzoxazepine derivatives. These compounds with potential drug value which exhibit a broad spectrum biological and pharmacological activities were successfully accessed with vitamin C catalytic system under environmentally friendly conditions in water. The main advantages of this protocol are operational simplicity, mild reaction conditions, high yields in short reaction time and good substrate generality.

Graphical abstract

Keywords

Ascorbic acid Green chemistry Heterocyclic compounds Multi-component reactions 

Notes

Acknowledgements

We gratefully acknowledge financial support of the Research Council of Shahid Beheshti University and the Iran National Science Foundation (INSF).

Compliance with ethical standards

Conflicts of interest

All authors declare that they have no conflict of interest.

Supplementary material

13738_2019_1655_MOESM1_ESM.docx (19.1 mb)
Supplementary material 1 (DOCX 19579 kb)

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Copyright information

© Iranian Chemical Society 2019

Authors and Affiliations

  1. 1.Faculty of ChemistryShahid Beheshti University, G.C.TehranIran

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