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Alpha-Casein: an efficient, green, novel, and eco-friendly catalyst for one-pot multi-component synthesis of bis (pyrazol-5-ols), dihydro-pyrano[2,3-c]pyrazoles and spiropyranopyrazoles in an environmentally benign manner

  • Jalili Milani
  • Malek Taher MaghsoodlouEmail author
  • Nourallah Hazeri
  • Mahmoud Nassiri
Original Paper
  • 6 Downloads

Abstract

For the first time, alpha-Casein was used as an efficient and eco-friendly catalyst for an effective and facile preparation of dihydropyranopyrazoles and spiropyranopyrazoles. The synthesis of bis (pyrazol-5-ols) derivatives was developed via one-pot, pseudo-five-component condensation, and the target dihydropyrano[2,3-c]pyrazoles and spiropyranopyrazoles were prepared by one-pot four-component reaction. This new method of employing alpha-Casein, which is a green, recyclable, non-toxic and commercially available catalyst, offers advantages such as mild condition, short reaction times, easy work-up, no need for column chromatography, and high yields of the products which make it more economic than other environmentally synthetic protocols.

Keywords

Alpha-Casein Novel catalyst One-pot Bis(pyrazole-5-ols) Spiropyranopyrazoles Dihydropyrano[2,3-c]pyrazoles 

Notes

Acknowledgements

The authors would like to acknowledge the financial support received from the Research Council of Sistan and Balouchestan University.

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Copyright information

© Iranian Chemical Society 2019

Authors and Affiliations

  • Jalili Milani
    • 1
  • Malek Taher Maghsoodlou
    • 1
    Email author
  • Nourallah Hazeri
    • 1
  • Mahmoud Nassiri
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceUniversity of Sistan and BaluchestanZahedanIran
  2. 2.Department of Marine Chemistry, Faculty of Marine ScienceChabahar Maritime UniversityChabaharIran

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