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Ultrasound aided solvent-free synergy: an improved synthetic approach to access 3,4-dihydropyrimidin-2(1H)-ones

  • Rathinam Ramesh
  • Samikannu Ramesh
  • Jan Grzegorz Malecki
  • Appaswami LalithaEmail author
Original Paper
  • 3 Downloads

Abstract

A remarkably simple synthetic method has been described for the access of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones in excellent yields in the presence of 2,4,6-trichloro-1,3,5-triazine (TCT) as an efficient source of hydrochloric acid under ultrasound radiation. In this tandem reaction, a range of aldehydes, β-diketo esters and urea were made to condense together via one-pot, solvent-free synthetic strategy. Use of metal-free catalyst, readily accessible substrates, high production rate and ease of work-up are the imperative features of this protocol.

Graphical abstract

Keywords

3,4-Dihydropyrimidin-2(1H)-ones Solvent-free synthesis Trichlorotriazine X-ray analysis Ultrasound 

Notes

Acknowledgements

R. Ramesh (IF120729) gratefully thank the financial assistance from Department of Science and Technology (Grant No: DST/INSPIRE Fellowship/2012/690) New Delhi, India.

Supplementary material

13738_2019_1597_MOESM1_ESM.doc (841 kb)
Supplementary material 1 (DOC 841 KB)
13738_2019_1597_MOESM2_ESM.pdf (131 kb)
Supplementary material 2 (PDF 130 KB)
13738_2019_1597_MOESM3_ESM.cif (221 kb)
Supplementary material 3 (CIF 221 KB)

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Copyright information

© Iranian Chemical Society 2019

Authors and Affiliations

  1. 1.Department of ChemistryPeriyar UniversitySalemIndia
  2. 2.Department of CrystallographyUniversity of SilesiaKatowicePoland

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