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Designing of homo and heteroleptic zinc(II) carboxylates: synthesis, spectroscopic characterizations, DNA binding study, CTAB interaction and in vitro antimicrobial evaluations

  • Kaleem Ullah
  • Muhammad SirajuddinEmail author
  • Muhammad Zubair
  • Ali Haider
  • Saqib Ali
  • Faizan Ullah
  • Grzegorz Dutkiewicz
  • Maciej Kubicki
  • Corrado Rizzoli
Original Paper
  • 54 Downloads

Abstract

Synthesis of two homoleptic and five heteroleptic zinc (II) carboxylate complexes with two different ligands: HL1 = 3-chlorobenzoic acid and HL2 = 2-(4-chlorophenyl) acetic acid have been reported in this paper. The general formulae of the two homoleptic complexes are: Zn(L1)2(1), and Zn(L2)2(2). Similarly, the general formulae for two different types of heteroleptic complexes are: (Type-I): [(Zn)2(L1)4(bipy)2(H2O)] (3), [Zn(L2)2(bipy)(H2O)] (4) and (Type-II): [ZnL1L2] (5), [ZnL1L2(py)] (6) and [ZnL1L2(bipy)] (7). The synthesized complexes were characterized in the solid state by FT-IR, CHN analyses and in solution state by NMR (1H, 13C) spectroscopy. Complexes 3 and 4 were also characterized by single crystal analysis where data revealed that the geometry around each Zn atom is distorted trigonal bipyramidal and octahedral, respectively. The synthesized complexes were interacted with SS-DNA and CTAB (surfactant). Interaction of the synthesized compounds with SS-DNA was studied by UV–visible spectroscopy and viscometry and intercalative mode of interaction was exhibited. Moreover, the interaction of the synthesized complexes with CTAB was studied by conductometry showing a strong binding that is evident from higher CMC and negative Gibbs free energy of micellization (ΔGm) values. The tested compounds were further screened for in vitro antibacterial and antifungal activities and were found active against the studied strains of bacteria and fungus.

Keywords

Zn carboxylates Spectroscopic characterization DNA interaction CTAB interaction Antimicrobial activity 

Notes

Acknowledgements

Higher Education Commission Islamabad Pakistan is highly acknowledgment by M. Sirajuddin for financial aid, Grant No. 6796/KPK/NRPU/R&D/HEC/2016.

Supplementary material

13738_2019_1594_MOESM1_ESM.doc (965 kb)
Supplementary material 1 (DOC 965 KB)

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Copyright information

© Iranian Chemical Society 2019

Authors and Affiliations

  • Kaleem Ullah
    • 1
  • Muhammad Sirajuddin
    • 2
    Email author
  • Muhammad Zubair
    • 1
  • Ali Haider
    • 1
  • Saqib Ali
    • 1
  • Faizan Ullah
    • 3
  • Grzegorz Dutkiewicz
    • 4
  • Maciej Kubicki
    • 4
  • Corrado Rizzoli
    • 5
  1. 1.Department of ChemistryQuaid-i-Azam UniversityIslamabadPakistan
  2. 2.Department of ChemistryUniversity of Science and Technology BannuBannuPakistan
  3. 3.Department of BotanyUniversity of Science and Technology BannuBannuPakistan
  4. 4.Department of ChemistryAdam Mickiewicz University in PoznanPoznanPoland
  5. 5.Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Centro di Studio per la Strutturistica Diffrattometrica del C.N.R.Università di ParmaParmaItaly

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