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Journal of the Iranian Chemical Society

, Volume 16, Issue 3, pp 493–500 | Cite as

Green approach to synthesis of new series of 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives

  • Abdollah Morshedi
  • Hamid Reza ShaterianEmail author
Original Paper
  • 13 Downloads

Abstract

One-pot, three-component condensation reaction between (phenylsulfonyl)acetonitrile, aromatic aldehydes, and 6-aminouracil for preparation of 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been reported. The method involves domino Knoevenagel condensation/Michael addition, and cyclization cascade. The reaction was performed in glycerol which is commercially available, inexpensive and non-toxic compound. High purity of the products, very high yields and wide scope of substrates are advantages of this protocol.

Keywords

6,8a-dihydropyrido[2,3-d]pyrimidine (Phenylsulfonyl)acetonitrile Glycerol Green chemistry Multi-component reactions 

Notes

Acknowledgements

We gratefully appreciate the University of Sistan and Baluchestan Research Councils for the financial support of this work.

Supplementary material

13738_2018_1528_MOESM1_ESM.docx (2.8 mb)
Supplementary material 1 (DOCX 2910 KB)

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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of SciencesUniversity of Sistan and BaluchestanZahedanIran

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