Journal of the Iranian Chemical Society

, Volume 16, Issue 3, pp 479–492 | Cite as

γ-Aminobutyric acid hydrochloride supported on superparamagnetic γ-Fe2O3@SiO2 as a novel heterogeneous nanocatalyst for the synthesis of 2-amino-5-alkylidene-thiazol-4-one derivatives

  • Hadi Mohammadi
  • Hamid Reza ShaterianEmail author
Original Paper


γ-Aminobutyric acid hydrochloride immobilized on superparamagnetic γ-Fe2O3@SiO2 nanoparticles as a novel heterogeneous nanocatalyst was prepared for the first times. It was characterized by several techniques such as XRD, FT-IR, VSM, FE-SEM, EDS, and TGA analysis. The heterogeneous nanocatalyst was used for a convenient, mild, and one-pot efficient three-component preparation of 2-amino-5-alkylidene-thiazol-4-one derivatives under green conditions at room temperature. The main advantage of the method is easily recovery of the stable nanocatalyst by an external magnet from the reaction mixture.


Nano-γ-Fe2O3@SiO2@[CH2)3-(γ-aminobutyric acid.HCl)] Superparamagnetic nanocatalyst 2-Amino-5-alkylidene-thiazol-4-ones Three-component reaction, Green reaction 



We are grateful for financial support from the Research Council of University of Sistan and Baluchestan.

Supplementary material

13738_2018_1527_MOESM1_ESM.docx (825 kb)
Supplementary material 1 (DOCX 824 KB)


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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of SciencesUniversity of Sistan and BaluchestanZahedanIran

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