Journal of the Iranian Chemical Society

, Volume 16, Issue 2, pp 325–332 | Cite as

One-pot synthesis of quinoline-fused [1,4]thiazepines via the tandem Ugi/post-Ugi reactions

  • Mehdi GhandiEmail author
  • Irene Efteghar
  • Alireza Abbasi
Original Paper


A one-pot strategy has been developed for the synthesis of novel tetrahydro-[1,4]thiazepino[7,6-b]quinoline-5-carboxamide derivatives. These reactions presumably proceed by the combination of a Ugi 4CR and three intramolecular SN2 aliphatic, an alkaline hydrolysis and an intramolecular cyclization SNAr nucleophilic substitution processes in moderate to good yields. Unambiguous assignment of the molecular structures was carried out by single-crystal X-ray diffraction.


Pyrrolidine-2-ones Ugi reaction Piperazines 



The authors acknowledge the University of Tehran for financial support of this research.


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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  1. 1.School of Chemistry, College of ScienceUniversity of TehranTehranIran

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