Nickel-catalyzed denitrative etherification of activated nitrobenzenes
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Electron-deficient nitrobenzenes were coupled with phenols/alcohols to form diaryl/alkyl aryl ethers by the aid of NiCl2 as the catalyst. The reactions were conducted under ligand- and oxidant-free conditions without the exclusion of air or moisture. The initial studies upon the mechanism of the reaction revealed two solvent-dependent approaches. In molten TBAB, SNAr mechanism seems to be predominated, while, in DMF, the reaction might include the radical species.
KeywordsDenitrative etherification Cross coupling Nickel Nitrobenzenes Green conditions
The authors are thankful to INSF (Grant number: 95825781) and University of Hormozgan research council for the financial support.
- 12.H. Wang, A. Yu, A. Cao, J. Chang, Y. Wu, Appl. Organomet. Chem. 27, 611 (2013)Google Scholar
- 23.T. Begum, M. Mondal, M.P. Borpuzari, R. Kar, P.K. Gogoi, U. Bora, Eur. J. Org. Chem. 3244 (2017)Google Scholar
- 26.ICP analysis revealed that no detectable Ni, Pd and Rh were present in TBAB. The detected amounts of Cu and Fe were 6 and 13 ppm, respectivelyGoogle Scholar