Journal of the Iranian Chemical Society

, Volume 16, Issue 1, pp 111–116 | Cite as

Metal-free greener method for the synthesis of densely functionalized pyrroles via a one-pot three-component reaction

  • Maryam Fatahpour
  • Nourallah Hazeri
  • Malek Taher Maghsoodlou
  • Mojtaba Lashkari
Original Paper


A convenient and straightforward acid-promoted synthesis of a new series of polyfunctionalized pyrroles has been developed based on a one-pot three-component reaction of acetoacetanilide, benzoin, and ammonium acetate/diverse anilines in acetic acid as a green solvent at 100 °C. The other salient benefits of this transformation include being simple reaction conditions, toxic transition-metal-free, no need of column chromatographic purification, moderate to good yields, eco-friendliness, and readily available starting materials.

Graphical abstract


Acid-promoted Polyfunctionalized pyrroles One-pot Green solvent 



We gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.


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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  • Maryam Fatahpour
    • 1
  • Nourallah Hazeri
    • 1
  • Malek Taher Maghsoodlou
    • 1
  • Mojtaba Lashkari
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceUniversity of Sistan and BaluchestanZahedanIran
  2. 2.Faculty of ScienceVelayat UniversityIranshahrIran

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