CEN Case Reports

, Volume 8, Issue 2, pp 79–82 | Cite as

Sarcoidosis in the renal allograft of a recipient whose primary disease was autosomal dominant polycystic kidney disease

  • Takahiro ShinzatoEmail author
  • Taro Kubo
  • Toshihiro Shimizu
  • Koji Nanmoku
  • Takashi Yagisawa
Case Report


We report a 55-year-old man with a renal allograft that developed sarcoidosis. His autosomal dominant polycystic kidney disease (ADPKD) progressed to end-stage stage renal disease when he was 52 years old, and he underwent living-donor kidney transplantation at the age of 53 years. His proteinuria worsened at 19 months post-transplantation, and his renal function began to decline at 29 months post-transplantation. A renal allograft biopsy performed at 31 months post-transplantation revealed non-caseating granulomatous interstitial nephritis. The patient was treated with prednisolone (0.5 mg/kg/day), with gradual reduction in the dose. His proteinuria improved and renal function did not deteriorate any further. To the best of our knowledge, this is the first case of sarcoidosis in a renal allograft recipient whose primary renal disease was ADPKD.


Sarcoidosis Kidney transplantation Autosomal dominant polycystic kidney disease 


Compliance with ethical standards

Conflict of interest

All the authors have declared no competing interest.

Human and animal rights

This article does not contain any studies with human participants performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.


  1. 1.
    Bagnasco SM, Gottipati S, Kraus E, Alachkar N, Montgomery RA, Racusen LC, Arend LJ. Sarcoidosis in native and transplanted kidneys: incidence, pathologic findings, and clinical course. PLoS One. 2014;9(10):e110778.CrossRefGoogle Scholar
  2. 2.
    Mann DM, Fyfe B, Osband AJ, Lebowitz J, Laskow DA, Jones J, Mann RA. Sarcoidosis within a renal allograft: a case report and review of the literature. Transplant Proc. 2013;45(2):838–41.CrossRefGoogle Scholar
  3. 3.
    Nunota N, Honda H, Shibata T, Yoshitake O, Murakami M, Sanada D, Yokochi A, Kato N, Kuroki A, Honda K, Yamaguchi Y, Sugisaki T, Akizawa T. Granulomatous interstitial nephritis in a renal allograft. CEN Case Rep. 2012;1(1):12–5.CrossRefGoogle Scholar
  4. 4.
    Aouizerate J, Matignon M, Kamar N, Thervet E, Randoux C, Moulin B, Raffray L, Buchler M, Villar E, Mahevas M, Desvaux D, Dahan K, Diet C, Audard V, Lang P, Grimbert P. Renal transplantation in patients with sarcoidosis: a French multicenter study. Clin J Am Soc Nephrol. 2010;5(11):2101–8.CrossRefGoogle Scholar
  5. 5.
    Vargas F, Gedalia A, Craver RD, Matti Vehaskari V. Recurrence of granulomatous interstitial nephritis in transplanted kidney. Pediatr Transplant. 2010;14(5):e54–7.CrossRefGoogle Scholar
  6. 6.
    Kukura S, Viklicky O, Lácha J, Voska L, Honsová E, Teplan V. Recurrence of sarcoidosis in renal allograft during pregnancy. Nephrol Dial Transplant. 2004;19(6):1640–2.CrossRefGoogle Scholar
  7. 7.
    Brown JH, Jos V, Newstead CG, Lawler W. Sarcoid-like granulomata in a renal transplant. Nephrol Dial Transplant. 1992;7(2):173.CrossRefGoogle Scholar
  8. 8.
    Shen SY, Hall-Craggs M, Posner JN, Shabazz B. Recurrent sarcoid granulomatous nephritis and reactive tuberculin skin test in a renal transplant recipient. Am J Med. 1986;80(4):699–702.CrossRefGoogle Scholar
  9. 9.
    Mahévas M, Lescure FX, Boffa JJ, Delastour V, Belenfant X, Chapelon C, Cordonnier C, Makdassi R, Piette JC, Naccache JM, Cadranel J, Duhaut P, Choukroun G, Ducroix JP, Valeyre D. Renal sarcoidosis: clinical, laboratory, and histologic presentation and outcome in 47 patients. Medicine (Baltimore). 2009;88(2):98–106.CrossRefGoogle Scholar

Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  1. 1.Department of Renal Surgery and TransplantationJichi Medical University HospitalShimotsukeJapan

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