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CEN Case Reports

, Volume 7, Issue 2, pp 198–203 | Cite as

Warfarin-related nephropathy with acute kidney injury in a patient with immunoglobulin A nephropathy

  • Hiroki Ishii
  • Keiji Hirai
  • Katsunori Yanai
  • Taisuke Kitano
  • Mitsutoshi Shindo
  • Haruhisa Miyazawa
  • Kiyonori Ito
  • Yuichiro Ueda
  • Yoshio Kaku
  • Taro Hoshino
  • Honami Mori
  • Susumu Ookawara
  • Yoshihiko Ueda
  • Yoshiyuki Morishita
Case Report
  • 62 Downloads

Abstract

A 55-year-old man with Marfan syndrome taking warfarin for anticoagulant therapy after aortic valve replacement developed acute kidney injury (serum creatinine level of 9.01 mg/dL) and gross macrohematuria. Renal biopsy showed red cell casts in the renal tubules, glomerular crescent formation in the glomeruli with immunoglobulin A deposition, and global sclerosis. Based on these findings, the patient was diagnosed with warfarin-related nephropathy with acute kidney injury characterized by immunoglobulin A nephropathy with crescents. The warfarin was withdrawn, and his hematuria and renal function improved without immunosuppressive agents.

Keywords

Acute kidney injury Warfarin-related nephropathy Immunoglobulin A nephropathy Crescents 

Notes

Compliance with ethical standards

Conflict of interest

The authors have declared that no conflict of interest exists.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the patient in this case report.

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Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  • Hiroki Ishii
    • 1
  • Keiji Hirai
    • 1
  • Katsunori Yanai
    • 1
  • Taisuke Kitano
    • 1
  • Mitsutoshi Shindo
    • 1
  • Haruhisa Miyazawa
    • 1
  • Kiyonori Ito
    • 1
  • Yuichiro Ueda
    • 1
  • Yoshio Kaku
    • 1
  • Taro Hoshino
    • 1
  • Honami Mori
    • 1
  • Susumu Ookawara
    • 1
  • Yoshihiko Ueda
    • 2
  • Yoshiyuki Morishita
    • 1
  1. 1.Division of Nephrology, First Department of Integrated Medicine, Saitama Medical CenterJichi Medical UniversitySaitamaJapan
  2. 2.Department of Diagnostic PathologyDokkyo University Koshigaya Medical CenterSaitamaJapan

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