CEN Case Reports

, Volume 6, Issue 2, pp 140–147 | Cite as

Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury

  • Tomoe Okubo
  • Shuma Hirashio
  • Minako Shimizu
  • Yoshiaki Kuroda
  • Shigehiro Doi
  • Takao MasakiEmail author
Case report


Acute kidney injury (AKI) because of bilateral renal infiltration is an uncommon presentation of diffuse large B-cell lymphoma (DLBCL). A 52-year-old man presented to our institution with AKI and complaints of fatigue. Ultrasonography revealed a large, 15 cm granulomatous mass arising from the bilateral kidneys. The mass was biopsied laparoscopically, and histopathological analysis revealed evidence of DLBCL. The patient subsequently underwent R-CHOP therapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Chemotherapy resulted in a rapid decrease in mass size and improvement in kidney function. However, after five courses of R-CHOP, relapse was observed in the central nervous system, and the patient died 220 days after the initial onset of AKI. Post-mortem analysis of renal tissue confirmed the initial diagnosis of DLBCL-associated renal infiltration. To our knowledge, this is the first report of DLBCL presenting as bilateral renal infiltration and AKI.


Diffuse large B-cell lymphoma Acute kidney injury Kidney infiltration Central nervous system relapse 



We thank “Edanz Editing®” for editing our manuscript.

Author contributions

All authors treated the patient, and made decisions regarding the patient’s examinations and therapies. TO reviewed the previous publications and drafted the manuscript. SH, MS, SD, and TM supervised the generation of the manuscript. TO and YK were principal physicians of the patient, and treated him on both an inpatient and outpatient basis. All authors contributed to the interpretation of the disease etiology and discussion. All authors have read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

Human and animal rights

This article does not contain studies with human or animal participants.

Informed consent



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Copyright information

© Japanese Society of Nephrology 2017

Authors and Affiliations

  • Tomoe Okubo
    • 1
  • Shuma Hirashio
    • 1
    • 2
  • Minako Shimizu
    • 1
  • Yoshiaki Kuroda
    • 3
    • 4
  • Shigehiro Doi
    • 1
  • Takao Masaki
    • 1
    Email author
  1. 1.Department of NephrologyHiroshima University HospitalHiroshimaJapan
  2. 2.Department of NephrologyNational Hospital Organization Higashihiroshima Medical CenterHiroshimaJapan
  3. 3.Department of HematologyHiroshima University HospitalHiroshimaJapan
  4. 4.Division of Stem Cell RegulationCenter for Molecular Medicine, Jichi Medical UniversityTochigiJapan

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