Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury
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Acute kidney injury (AKI) because of bilateral renal infiltration is an uncommon presentation of diffuse large B-cell lymphoma (DLBCL). A 52-year-old man presented to our institution with AKI and complaints of fatigue. Ultrasonography revealed a large, 15 cm granulomatous mass arising from the bilateral kidneys. The mass was biopsied laparoscopically, and histopathological analysis revealed evidence of DLBCL. The patient subsequently underwent R-CHOP therapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Chemotherapy resulted in a rapid decrease in mass size and improvement in kidney function. However, after five courses of R-CHOP, relapse was observed in the central nervous system, and the patient died 220 days after the initial onset of AKI. Post-mortem analysis of renal tissue confirmed the initial diagnosis of DLBCL-associated renal infiltration. To our knowledge, this is the first report of DLBCL presenting as bilateral renal infiltration and AKI.
KeywordsDiffuse large B-cell lymphoma Acute kidney injury Kidney infiltration Central nervous system relapse
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All authors treated the patient, and made decisions regarding the patient’s examinations and therapies. TO reviewed the previous publications and drafted the manuscript. SH, MS, SD, and TM supervised the generation of the manuscript. TO and YK were principal physicians of the patient, and treated him on both an inpatient and outpatient basis. All authors contributed to the interpretation of the disease etiology and discussion. All authors have read and approved the final manuscript.
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Conflict of interest
The authors declare that there are no conflicts of interest.
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This article does not contain studies with human or animal participants.