CEN Case Reports

, Volume 6, Issue 2, pp 136–139 | Cite as

Cavernous sinus thrombosis in a patient with nephrotic syndrome

  • David NavarroEmail author
  • Ana Carina Ferreira
  • Helena Viana
  • Fernanda Carvalho
  • Fernando Nolasco
Case report


Nephrotic syndrome (NS) is a glomerular disease characterized by altered permeability of the glomerular capillary wall to macromolecules. This results in heavy proteinuria, hypoalbuminemia, hypercholesterolemia, lipiduria, and edema.

This clinical and laboratory syndrome is a life-threatening disease, and is associated with several complications, not only related to the disease itself, but also related to its treatment.

Disease-associated complications include acute kidney injury, chronic kidney disease, cardiovascular disease, negative nitrogen balance, infections, endocrine disorders, and hypercoagulability.

Venous and arterial thromboembolism is a significant complication of NS, occurring in approximately 27% of the patients [1]. This represents an 800% increase relatively to the general population [1, 2]. The pathophysiology of thrombogenesis in NS is not fully understood, and seems to be multifactorial [3], depending on the etiology (particularly frequent in...


Compliance with ethical standards

Conflict of interest

All the authors have declared no competing interest.

Human and animal rights statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Japanese Society of Nephrology 2017

Authors and Affiliations

  1. 1.Hospital Curry Cabral, Centro Hospitalar Lisboa CentralLisbonPortugal

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