Advertisement

CEN Case Reports

, Volume 6, Issue 2, pp 132–135 | Cite as

Primary Ewing sarcoma of the kidney: a case report and treatment review

  • Muhammad Sadiq
  • Iftikhar AhmadEmail author
  • Jamila Shuja
  • Khushnaseeb Ahmad
Case report

Abstract

Ewing sarcomas/primitive neuroectodermal tumors (ES/PNET) of the kidney are rarely found high-grade malignant tumors, offering poor prognosis. Although established treatment guidelines for ES of kidney are scarce, a multi-modality treatment approached is typically implemented. Herein, we report a 14-year-old female patient with ES of right kidney. Post-nephrectomy disease recurrence was treated with chemotherapy (i.e., vincristine, doxorubicin and cyclophosphamide); marked reduction in tumor size (i.e., from 18.5 × 11.3 cm2 to 3.7 × 2.2 cm2; ~96% reduction in size) as per computed tomography images was observed. We present our treatment experience and review from the available literature.

Keywords

Chemotherapy Disease recurrence Ewing sarcoma kidney Radiotherapy Nephrectomy 

Notes

Compliance with ethical standards

Conflict of interest

It is declared that the results presented in this paper have not been published previously in whole or part. Furthermore, the authors have no conflict of interest.

References

  1. 1.
    Zollner S, Dirksen U, Jurgens H, Ranft A. Renal wing tumors. Ann Oncol. 2013;24:2455–61.CrossRefGoogle Scholar
  2. 2.
    Karpate A, Menon S, Basak R, Yuvaraja TB, Tongaonkar HB, Desai SB. Ewing sarcoma/primitive neuroectodermal tumor of the kidney: clinicopathologic analysis of 34 cases. Ann Diagn Pathol. 2012;16(4):267–74.CrossRefGoogle Scholar
  3. 3.
    Huang J, Zhang J, Dong B, Clien Y, Kong W, Liu Q, et al. Primitive neuroectodermal tumor of the kidney: a single-institute series of six patients from China. Urol Int. 2013;90:174–8.CrossRefGoogle Scholar
  4. 4.
    Liu Z, Wang X, Lu Y, Chen L, Lu Y. Primary Ewing sarcoma/primitive neuroectodermal tumor of the renal pelvis: a case report. World J Surg Oncol. 2014;12(293):1–3.Google Scholar
  5. 5.
    Rodriguez-galindo C, Marina NM, Fletcher BD, Parham DM, Bodner SM, Meyer WH. Is primitive neuroectodermal tumor of the kidney a distinct entity? Cancer. 1997;79:2243–50.CrossRefGoogle Scholar
  6. 6.
    Thyavihally YB, Tongaonkar HB, Gupta S, Kurkure PA, Amare P, Muckaden MA, et al. Primitive neuroectodermal tumor of the kidney: a single institute series of 16 patients. Urology. 2008;71(2):292–6.CrossRefGoogle Scholar
  7. 7.
    Grier HE, Krailo MD, Tarbell NJ, MichaelLink MP, Fryer CJH, Pritchard DJ, et al. Addition of Ifosfamide and Etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003;348(8):694–701.CrossRefGoogle Scholar
  8. 8.
    Castro EC, Parwani AV, Ewing sarcoma/primitive neuroectodermal tumor of the kidney: two unusual presentations of a rare tumor. Case Rep Med. 2012;2012. doi: 10.1155/2012/190581 CrossRefGoogle Scholar
  9. 9.
    Chakrabarti N, Dewasi N, Das S, Bandyopadhyay A, Bhadure N. Primary Ewing’ s sarcoma/primitive neuroectodermal tumor of kidney—a diagnostic dilemma. Iran J Cancer Prev. 2015;8(2):129–33.PubMedPubMedCentralGoogle Scholar
  10. 10.
    Kuczynski AP, Gugelmin ES, Netto RAS. Primitive neuroectodermal tumor of the kidney in children. J Pediatia. 2001;77(1):49–51.CrossRefGoogle Scholar
  11. 11.
    Richey SL, Rao P, Wood CG, Patel S, Tannir NM. Metastatic extraosseous Ewing’ s sarcoma (EES)/primitive neuroectodermal tumor (PNET) of the kidney: 8-year durable response after induction and maintenance chemotherapy. Clin Genitourin Cancer. 2012;10(3):210–2.CrossRefGoogle Scholar
  12. 12.
    Miser J, Kinsella T, Triche T, Steis R, Tsokos M, Wesley R, et al. Treatment of peripheral neuroepithelioma in children and young adults. J Clin Oncol. 1987;5(11):1752–8.CrossRefGoogle Scholar
  13. 13.
    Hakky TS, Gonzalvo AA, Lockhart JL, Rodriguez AR. Primary Ewing sarcoma of the kidney: a symptomatic presentation and review of the literature. Ther Adv Urol. 2013;5(3):153–9.CrossRefGoogle Scholar

Copyright information

© Japanese Society of Nephrology 2017

Authors and Affiliations

  1. 1.Center for Nuclear Medicine and Radiotherapy (CENAR)QuettaPakistan

Personalised recommendations