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Cellulosic and acrylic polymers based composites for controlled drug release

  • Izza Tariq
  • Abid Mehmood YousafEmail author
  • Syed Atif Raza
  • Yasser Shahzad
  • Talib Hussain
  • Ikram Ullah Khan
  • Tariq Mahmood
  • Muhammad Jamshaid
Original Research
  • 28 Downloads

Abstract

The study focused on the preparation and in vitro characterization of sustained release polymeric systems or solid dispersions for highly water-soluble drugs. Several polymeric composites were fabricated with ethyl cellulose (EC), Eudragit S100 (E-S100) or Eudragit RS100 (E-RS100) in conjunction with hydroxypropyl methylcellulose (HPMC) using 5-fluorouracil (5-FU) as a model drug. The solvent-evaporated composites were evaluated for in vitro release of the drug. In this respect, various mathematical models were applied to assess the release kinetics. Further characterization was accomplished by X-ray diffraction (XRD) analysis, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Formulations comprising 5-FU/HPMC/(EC, E-S100 or E-RS100) at the weight ratio of 1/1/3 (formulations III, V and VI) significantly reduced the burst effect in vitro as compared to the plain drug powder. In particular, EC provided better sustained release effect compared with E-S100 and E-RS100 (~ 70% versus 85–87% in 8 h). The effect of higher quantity of EC on drug release was tested with a formulation containing 5-FU/HPMC/EC at the weight ratio of 1/1/4 (formulation IV). The drug was present in the amorphous state of all the above formulations. Thus, these formulations, in particular formulation IV, might be promising delivery systems to circumvent the burst effect caused by highly water-soluble drugs.

Keywords

Burst effect Cellulosic polymer Eudragit Sustained release solid dispersion Polymeric composite 

Notes

Acknowledgements

The authors are thankful to Rashid Latif College of Pharmacy (Lahore, Pakistan), University of Central Punjab (Lahore, Pakistan) and COMSATS University Islamabad (Lahore Campus, Lahore, Pakistan) for providing materials and laboratory facilities for accomplishing the present research work.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Iran Polymer and Petrochemical Institute 2019

Authors and Affiliations

  1. 1.Faculty of PharmacyUniversity of Central PunjabLahorePakistan
  2. 2.Drug Delivery Research Group, Department of PharmacyCOMSATS University Islamabad, Lahore CampusLahorePakistan
  3. 3.Punjab University College of PharmacyUniversity of the PunjabLahorePakistan
  4. 4.Department of Pharmaceutics, Faculty of Pharmaceutical SciencesGovernment College UniversityFaisalabadPakistan

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