Advertisement

International Cancer Conference Journal

, Volume 8, Issue 2, pp 47–57 | Cite as

Systematic review of case reports of Japanese esophageal neuroendocrine cell carcinoma in the Japanese literature

  • Yoshinori Kikuchi
  • Hideaki ShimadaEmail author
  • Kazuhisa Yamaguchi
  • Yoshinori Igarashi
Review article
  • 24 Downloads

Abstract

Esophageal neuroendocrine cell carcinoma (NEC) is extremely rare, and its treatment strategy has not been established. Systematic review and meta-analysis were carried out to assess the treatment and prognosis of patients with esophageal NEC in Japan. The Ichushi-Web database was searched from January 1964 to May 2018. In total, 141 cases of esophageal NEC were included in the analysis. The survival of the chemotherapy group with stage II/III esophageal NEC was better than that of the surgery group. Meanwhile, the survival of the adjuvant treatment group with stage II/III esophageal NEC was significantly better than that of the surgery alone group. In patients with stage IV esophageal NEC, no significant differences were observed in terms of treatment response from the three regimens: irinotecan/platinum and etoposide/platinum compared with 5-fluorouracil/platinum. Moreover, no significant differences were observed in the survival of patients who received the chemotherapy regimens. However, the 2-year survival rates of the irinotecan/platinum (26%) group and etoposide/platinum (27%) group were higher than that of the 5-fluorouracil/platinum (0%) group. In esophageal NEC, chemotherapy may be used as the first-line treatment. Irinotecan/platinum or etoposide/platinum can be the first-line regimen for chemotherapy. However, the additive effects of surgery remain unclear.

Keywords

Esophageal neuroendocrine cell carcinoma Surgery Chemotherapy Overall survival 

Abbreviation

NEC

Neuroendocrine cell carcinoma

Notes

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest associated with this manuscript.

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Ethical approval

Ethical approval is not required because all data in this study uses Ichushi-Web database.

Informed consent

Informed consent is not required because all data in this study uses Ichushi-Web database.

References

  1. 1.
    McKeown F (1952) Oat cell carcinoma of the esophagus. J Pathol Bacteriol 64:889–891CrossRefPubMedGoogle Scholar
  2. 2.
    Chino O, Makuuch H, Ozawa S et al (2017) Endoscopic diagnosis of the esophageal neuroendocrine cell carcinoma: its morphological and histopathological features and clinical problems. Stomach Intest 52:402–411. (in Japanese)Google Scholar
  3. 3.
    Japan Esophageal Society (2014) Guidelines for diagnosis and treatment of carcinoma of the esophagus. Kanehara, Tokyo (Japanese) Google Scholar
  4. 4.
    Tustumi F, Takeda FR, Uema RH et al (2017) Primary neuroendocrine neoplasm of the esophagus—report of 14 cases from a single institute and review of the literature. Arq Gastroenterol 54:4–10CrossRefPubMedGoogle Scholar
  5. 5.
    Deng H-Y, Ni P-Z, Wang Y-C et al (2016) Neuroendocrine carcinoma of the esophagus: clinical characteristics and prognostic evaluation of 49 cases with surgical resection. J Thorac Dis 8:1250–1256CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Hong L, Zhang Y, Liu Z (2018) Neuroendocrine carcinoma of esophageal and gastric cardia: clinicopathologic and immunohistochemistry study of 80 cases. Oncotarget 9:10754–10764PubMedGoogle Scholar
  7. 7.
    Japan Esophageal Society (2015) Guidelines for Diagnosis and Treatment of Neuroendocrine cell carcinoma of the Pancreas and Gsstriuntestinal. Kanehara, Tokyo (Japanese) Google Scholar
  8. 8.
    Kikuchi Y, Matsuzaki M, Tokura N et al (2009) Gastric small-cell carcinoma: analysis of cases at Toho University and in Japan. J Med Soc Toho 56:421–428 (in Japanese) Google Scholar
  9. 9.
    Kikuchi Y, Matsuzaki M, Tokura N et al (2010) Disseminated carcinomatosis of the bone marrow due to gastric cancer: Analysis of cases at Toho University and in Japan. J Med Soc Toho 57:127–136 (in Japanese)Google Scholar
  10. 10.
    Kikuchi Y, Hirose M, Otsuka T et al (2011) Survival and effectiveness of chemotherapy in Japanese patients with gastric metastasis: a case series. J Med Soc Toho 58:35–49 (in Japanese) Google Scholar
  11. 11.
    Kikuchi Y, Kishimoto Y, Ito K et al (2012) Peritoneal malignant mesothelioma: analysis of cases at Toho University and in Japan. J Med Soc Toho 59:174–182 (in Japanese) Google Scholar
  12. 12.
    Takeuchi M, Kobayashi M, Ajioka Y et al (2009) Primary esophageal endocrine cell carcinoma of small cell type, which was 4 mm in size and pT1a-MM in invasion depth, report of a case. Stomach Intest 44:1759–1766 (in Japanese) Google Scholar
  13. 13.
    Oyama T, Takahashi A, Miyata Y et al (2017) A case of superficial esophageal neuroendocrine carcinoma treated by endoscopic submucosal dissection and chemo-radiotherapy. Stomach Intest 52:461–468 (in Japanese) Google Scholar
  14. 14.
    Yamano T, Takahashi T, Hondo M et al (2008) Advanced small cell esophageal carcinoma with liver metastasis having a long survival; a case report. Nuclear Med Clinic 41:18–20 (in Japanese) Google Scholar
  15. 15.
    Kishino T, Oyama T, Tomori A et al (2011) Esophageal endocrine cell carcinoma; report of a case. Stomach Intest 46:781–787 (in Japanese) Google Scholar
  16. 16.
    Nagao M, Okamoto T, Nishimura J et al (2014) A case of endocrine cell carcinoma with gastric adenocarcinoma successfully treated by chemotherapy. Yamaguchi Med J 63:61–67 (in Japanese) CrossRefGoogle Scholar
  17. 17.
    Yokota M, Koike J, Sano M et al (2017) An elderly case of esophageal smal1 cel1 carcinoma responding to chemoradiotherapy. Progress Dig Endosc 90:78–79 (in Japanese) CrossRefGoogle Scholar
  18. 18.
    Takiyama W, Fujii M, Moriwaki S (1988) Small cell carcinoma of the esophagus: report of a case treated with Chemotherapy. Jpn J Surg 18:330–335CrossRefPubMedGoogle Scholar
  19. 19.
    Ogino M, Ogino Y, Sakai F et al (2005) A case of paraneoplastic neurological syndrome associated with small cell carcinoma of the esophagus with benign prognosis. Peripheral Nerve 16:130–133 (in Japanese) Google Scholar
  20. 20.
    Torii K, Kawabe J, Hayashi T et al (2004) A case of small cell carcinoma of the esophagus detected incidentally by FDG-PET. Ann Nucl Med 18:699–702CrossRefPubMedGoogle Scholar
  21. 21.
    Watanabe K, Ogata S, Nagata M et al (2003) A case of primary esophageal small cell type undifferentiated carcinoma. Stomach Intest 38:1604–1607 (in Japanese) Google Scholar
  22. 22.
    Wada D, Nishikawa K, Iwase K et al (2009) A case report of esophageal small cell carcinoma with peritoneal dissemination which could be treated temporality by chemotherapy. J Clin Surg 64:1145–1150 (in Japanese) Google Scholar
  23. 23.
    Hosokawa O, Kaizaki Y, Tanigawa K et al (2000) Esophageal small cell carcinoma followed up with endoscopy for one year and six months, report of a case. Stomach Intest 35:573–578 (in Japanese) Google Scholar
  24. 24.
    Yamaguchi E, Ito M, Matsuzaki S et al (1995) A case of primary small cell carcinoma in the esophagus. Nagasaki Med J 70:1–4 (in Japanese) Google Scholar
  25. 25.
    Uno T, Itami J, Shiina T et al (1993) A primary small cell carcinoma of the esophagus—a case of an aged patient given palliative irradiation -. Jpn J Cancer Clin 39:1565–1568 (in Japanese) Google Scholar
  26. 26.
    Okamoto K, Kanai H, Okamoto K et al (1998) An autopsy case of subacute cerebellar degeneration with small cell carcinoma of the esophagus. Clin Neurol 28:793–796 (in Japanese) Google Scholar
  27. 27.
    Ohtsu A, Yoshida S, Boku N et al (1993) Small cell carcinoma of the esophagus with an esophago-mediastinal fistula successfully treated by chemoradiation therapy and Intubation: a case report. Jpn J Clin Oncol 23:373–377PubMedGoogle Scholar
  28. 28.
    Ichimonji I, Ishizuka T, Yonezu M et al (2000) Rapidly progressive clinical course in a patient with small cell carcinoma of the esophagus diagnosed with liver biopsy. Jpn J Cancer Clin 46:912–915 (in Japanese) Google Scholar
  29. 29.
    Uchiada N, Akazawa S, Tanaka Y et al (1991) A case report of small cell carcinoma of the esophagus treated by chemotherapy alone. Jpn J Cancer Dig Organs 1:105–110 (in Japanese) Google Scholar
  30. 30.
    Tanabe S, Imamura K, Tanabe Y et al (1989) A case of report of small cell carcinoma of the esophagus with bone marrow metastasis. Progress Dig Endosc 34:232–235 (in Japanese) Google Scholar
  31. 31.
    Saitoh S, Yoda M, Kimura T (1993) Primary small cell carcinoma (SCC) of the esophagus. Med J Ushioda General Hosp 8:17–27Google Scholar
  32. 32.
    Sairenji T, Fujii Y, Eriguchi M (2001) A case of esophagus small cell carcinoma responding to chemotherapy with CPT-11. Jpn J Cancer Chemother 28:1283–1286 (in Japanese) Google Scholar
  33. 33.
    Yamamoto M, Kamiya K, Tanaka T et al (2008) Long-surviving case of advanced esophageal small cell carcinoma with a multidisciplinary treatment approach. Esophagus 5:99–103CrossRefGoogle Scholar
  34. 34.
    Takita M, Noutomi K, Suetsugu M et al (1987) A case of esophageal small cell carcinoma with miliary brain metastasis beginning with generalized convulsion. Clin Psychiatry 29:1341–1343 (in Japanese) Google Scholar
  35. 35.
    Shinohara Y, Takeno S, Takahashi Y et al (2014) Successful chemoradiotherapy for small-cell carcinoma of the esophagus in an octogenarian Japanese woman: report of the oldest case and review of long-term survival cases. Ann Thorac Cardiovasc Surg 20:237–242CrossRefPubMedGoogle Scholar
  36. 36.
    Furukawa Y, Tanaka Y, Mafune K et al (1996) A case of primary esophageal small cell carcinoma. J Saitama MS 30:877–882 (in Japanese) Google Scholar
  37. 37.
    Kotake K, Yoneyama K, Miyata J et al (1985) Small cell carcinoma (Oat cell type) of the esophagus—report of a case. J Jpn Soc Clin Surg 46:1107–1113 (in Japanese) Google Scholar
  38. 38.
    Zeze K, Nakashima K, Iyota N et al (1986) Two cases of oat cell carcinoma of the esophagus. J Jpn Soc Clin Surg 47:1588–1594 (in Japanese) Google Scholar
  39. 39.
    Sugiyama A, Harada H, Kumaki T et al (1990) A case of oat cell carcinoma of the esophagus. Endosc Forum Dig Dis 6:32–37 (in Japanese) Google Scholar
  40. 40.
    Takagi K, Tashiro T, Mashima Y et al (1993) Endocrine cell carcinoma of the esophagus—report of a case. J Jpn Soc Clin Surg 54:946–950 (in Japanese) Google Scholar
  41. 41.
    Ozawa Y, Inagaki Y, Yonei Y et al (1993) Oat cell carcinoma of the esophagus: report of a case. J Jpn Soc Cancer Ther 28:929–935 (in Japanese) Google Scholar
  42. 42.
    Muto I, Nishimaki T, Aizawa K et al (1995) Primary small cell carcinoma of the esophagus: report of a case. Surg Today 25:830–833CrossRefPubMedGoogle Scholar
  43. 43.
    Komada H, Kawaguchi Y, Nakagawa A et al (1996) A case report of small cell carcinoma of the esophagus treated with multidisciplinary treatment. J Jpn Soc Clin Surg 57:1120–1124 (in Japanese) Google Scholar
  44. 44.
    Kumegawa H, Tanaka T, Mori S et al (1996) A case report of small cell carcinoma of the esophagus with remarkable response to neoadjuvant chemotherapy. Jpn J Cancer Chemother 23:487–490 (in Japanese) Google Scholar
  45. 45.
    Sano T, Akao M (1996) A case of small cell carcinoma (oat-cell type) of the esophagus. J Jpn Assn Thorac Surg 44:955–958 (in Japanese) Google Scholar
  46. 46.
    Ohmura Y, Takiyama W, Mandai K et al (1997) Small cell carcinoma of the esophagus: a case report. Jpn J Clin Oncol 27:95–100CrossRefPubMedGoogle Scholar
  47. 47.
    Kuwabara H, Maruyama M, Yoshida T et al (1998) Early small cell carcinoma of the esophagus associated with Wernicke-Korsakoff Syndrome—report of a case. J Jpn Soc Clin Surg 59:127–131 (in Japanese) Google Scholar
  48. 48.
    Suda H, Tozawa H, Funakoshi K et al (1998) Small cell carcinoma of the esophagus—report of 3 case. Endosc Forum Dig Dis 14:146–50 (in Japanese) Google Scholar
  49. 49.
    Hosoya Y, Shibusawa H, Waki Y et al (1998) A case report of small cell carcinoma of the esophagus. J Jpn Soc Clin Surg 59:1833–1837 (in Japanese) Google Scholar
  50. 50.
    Ii K, Hirono M, Kitajima K et al (1999) Case of primary small cell carcinoma of the esophagus review of endoscopic features reported in the Japanese literatures. Gastroenterol Endosc 41:2368–2373 (in Japanese) Google Scholar
  51. 51.
    Tajiri M, Yamamoto O, Sugenaga Y et al (1999) A case of erythroderma associated with esophageal small cell carcinoma. Nishinihon J Dermatol 61:426–429 (in Japanese) CrossRefGoogle Scholar
  52. 52.
    Yoshikawa T, Kato H, Nikkuni K et al (1999) A case report of esophageal small cell carcinoma responding well to chemotherapy of 5-FU and cisplatin combined with radiotherapy. Gan To Kagaku Ryoho 26:1181–1184 (in Japanese) PubMedGoogle Scholar
  53. 53.
    Nakazawa K, Shiozawa S, Kubota S et al (1999) A case of primary small cell carcinoma of the esophagus. J Jpn Soc Clin Cytol 38:268–271 (in Japanese) CrossRefGoogle Scholar
  54. 54.
    Hayashi Y, Shindo H, Tachiyama Y et al (2000) Two cases of small cell carcinoma of esophagus concomitant with invasive squamous cell carcinoma and carcinoma in situ. Jpn J Diagn Pathol 17:372–375 (in Japanese) Google Scholar
  55. 55.
    Matsumoto H, Hanashi T, Yoshida M et al (2000) Small-cell carcinoma of the cervical esophagus, found one year after subtotal thoracic esophagectomy for early cancer—A case report. J Jpn Soc Clin Surg 61:356–361 (in Japanese) Google Scholar
  56. 56.
    Komoto D, Kayashima Y, Tomiyoshi H et al (2001) A case of esophageal small cell type undifferentiated carcinoma. Medl Bull Onomichi General Hosp 11:45–47 (in Japanese) Google Scholar
  57. 57.
    Nagahama T, Maruyama M, Tokairin Y et al (2001) A patient with small-cell carcinoma of the esophagus with synchronous liver metastasis surviving 48 months after surgery. Jpn J Cancer Chemother 28:1655–1658 (in Japanese) Google Scholar
  58. 58.
    Iwamura T, Shibata N, Termuhlen P et al (2001) Superficial neuroendocrine carcinoma of the esophagus. Dig Endosc 13:216–219 (in Japanese) CrossRefGoogle Scholar
  59. 59.
    Komura Y, Uemura N, Okamoto S et al (2001) A case of small cell carcinoma of esophagus successfully treated by chemotherapy with CPT-11 and CDDP. J Jpn Soc Gastroenterol 98:25–30 (in Japanese) Google Scholar
  60. 60.
    Takeshita H, Matsuzaki M, Kamiya I et al (2002) A case of small cell carcinoma of the esophagus relating rapidly after surgery. J Jpn Soc Clin Surg 63:2423–2427 (in Japanese) Google Scholar
  61. 61.
    Takada M, Takenouchi N (2002) A long-term survival patient with primary small-cell cancer of the esophagus. J Jpn Soc Clin Surg 63:357–360 (in Japanese) Google Scholar
  62. 62.
    Yamamoto J, Ohshima K, Kikuchi M et al (2003) Primary esophageal small cell carcinoma preoperatively diagnosed as esophageal squamous cell carcinoma; endoscopic findings and Histopathological Feature. Jpn J Cancer Clin 49:1417–1424 (in Japanese) Google Scholar
  63. 63.
    Kikuchi Y, Fujitsuka Y, Takeuchi M et al (2003) A case of esophageal small cell carcinoma responding to chemotherapy with 5-FU and Nedaplatin combined with radiation. Jpn J Cancer Clin 49:1451–1455 (in Japanese) Google Scholar
  64. 64.
    Tsujie M, Shibata N, Nomura T et al (2003) A patient with stage IVb small cell carcinoma of the esophagus who survived 23 months after systemic cancer chemotherapy. Jpn J Cancer Chemother 30:271–275 (in Japanese) Google Scholar
  65. 65.
    Koide N, Hiragauri M, Kishimoto K et al (2003) Small cell carcinoma of the esophagus with reference to alternating multiagent chemotherapy: report of two cases. Surg Today 33:294–298CrossRefPubMedGoogle Scholar
  66. 66.
    Noguchi T, Takeno S, Sato T et al (2003) Coexistent multiple adenocarcinomas arising Barrett’s esophagus 23 years after total gastrectomy and esophageal small cell carcinoma. Jpn J Thoracic Cardiovasc Surg 51:259–262CrossRefGoogle Scholar
  67. 67.
    Kubota M, Sueyoshi S, Fujita H et al (2003) Spontaneous regression in small cell esophageal carcinoma. Jpn J Thoracic Cardiovasc Surg 51:660–664CrossRefGoogle Scholar
  68. 68.
    Sugiura K, Ozawa S, Kitagawa Y et al (2004) A resected of a small cell carcinoma of the esophagus and analysis of cases in the literature. Jpn J Gastroenterol Surg 37:123–129 (in Japanese) CrossRefGoogle Scholar
  69. 69.
    Shioaki Y, Koide K, Kurioka H et al (2004) Case of superficial small cell carcinoma of the esophagus with liver metastasis. Gastroenterol Endosc 46:1340–1345 (in Japanese) Google Scholar
  70. 70.
    Takahashi T, Machida K, Honda N et al (2004) Extraosseous accumulation of 99mTc-MDP in lymph node metastases of small cell carcinoma of the esophagus. Ann Nucl Med 18:157–160. ACrossRefPubMedGoogle Scholar
  71. 71.
    Onishi Y, Fujisawa T, Maeda M et al (2004) Primary composite tumor with bipartite differentiation of the esophagogastric junction. Dig Endosc 16:66–70CrossRefGoogle Scholar
  72. 72.
    Matsuhashi N, Nagao N, Tanaka C et al (2004) Case of small cell carcinoma of the esophagus who failed to be diagnosed correctly by preoperative endoscopic biopsy. J Jpn College Surg 29:872–877 (in Japanese) CrossRefGoogle Scholar
  73. 73.
    Watanabe S, Udagawa I, Ishida Y (2004) A case report of esophageal small cell carcinoma; a long-term survival by radio-chemotherapy with carboplatin and etoposide. J Jpn Soc Gastroenterol 101:1217–1220 (in Japanese) Google Scholar
  74. 74.
    Hattori M, Kaizaki Y, Hosokawa O et al (2004) Esophageal endocrine cell carcinoma: report of a case. Stomach Intest 39:89–94 (in Japanese) Google Scholar
  75. 75.
    Kawai T, Yoshizumi Y, Tsuwano S et al (2004) A case of esophageal small cell carcinoma with survival 5 years after resection. J Saitama MS 39:207–211 (in Japanese) Google Scholar
  76. 76.
    Matsuoka M, Boku N, Yoshino T et al (2005) Small cell carcinoma of the esophagus responding to fourth-line chemotherapy with weekly paclitaxel. Int J Clin Oncol 10:429–432CrossRefPubMedGoogle Scholar
  77. 77.
    Kobayashi K, Aoki T, Nishioka K et al (2005) Superficial-type small cell-type undifferentiated carcinoma of the esophagus, Report of a case. Stomach Intest 40:1067–1072 (in Japanese) Google Scholar
  78. 78.
    Higashidani Y, Tamura S, Yokoyama Y et al (2005) Small cell carcinoma of the esophagus with metastasis to the brain: a case report. Esophagus 2:97–102CrossRefGoogle Scholar
  79. 79.
    Komoto M, Takashima T, Nakata B et al (2005) A case of esophageal carcinosarcoma of which carcinoma component was small cell carcinoma. Jpn J Gastroenterol Surg 38:31–35 (in Japanese) CrossRefGoogle Scholar
  80. 80.
    Nagahama T, Ando M, Ohbu M et al (2006) A case report of small cell carcinoma of the esophagus successfully treated by irinotecan and cisplatin. Jpn J Cancer Chemother 33:1869–1871 (in Japanese) Google Scholar
  81. 81.
    Akaike H, Kono K, Sugai H et al (2006) A case report of small cell carcinoma of the esophagus with difficulty in preoperative diagnosis and rapid progression. J Jpn College Surg 31:822–826 (in Japanese) CrossRefGoogle Scholar
  82. 82.
    Masuda R, Yasuda Y, Tarao H et al (2006) A case of esophageal small cell carcinoma. J Ther 88:2050–2053 (in Japanese) Google Scholar
  83. 83.
    Furihata M, Ono Y, Fujimori T et al (2006) Esophageal small cell carcinoma effectively treated by cisplatin and irinotecan. Esophagus 3:61–64CrossRefGoogle Scholar
  84. 84.
    Shimada T, Koizumi W, Tanabe S et al (2006) Small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome: a case report documenting a complete response. Jpn J Clin Oncol 36:109–112CrossRefGoogle Scholar
  85. 85.
    Mori N, Fujita H, Sueyoshi S et al (2006) Small cell carcinoma in the esophagus rapidly developing multiple fistulae. Esophagus 3:7–12CrossRefGoogle Scholar
  86. 86.
    Furukita Y, Taniki T, Fukui Y et al (2006) A resected case of small cell carcinoma of the esophagus. Med J Kochi Health Sci Center 1:33–37 (in Japanese) Google Scholar
  87. 87.
    Hashimoto T, Izumi Y, Oota M et al (2007) Superficial small cell carcinoma of esophagus treated be endoscopic mucosal resection combined with chemoradiotherapy. Jpn J Cancer Chemother 34:81–84 (in Japanese) Google Scholar
  88. 88.
    Kanno K, Hikichi T, Saito K et al (2007) A case of esophageal small cell carcinoma associated with hypercalcemia causing severe acute pancreatitis. Fukushima J Med Sci 53:51–60CrossRefPubMedGoogle Scholar
  89. 89.
    Goto T, Watanabe H, Kawakami T et al (2007) A case of small cell carcinoma of the esophagus with remarkable response to chemotherapy with CPT-11 and CDDP. J Jpn Soc Gastroenterol 104:1204–1211 (in Japanese) Google Scholar
  90. 90.
    Kontani T, Shimada K, Iwakura S et al (2007) A case of small cell carcinoma of the esophagus. J Wakayama Med Soc 58:84–86 (in Japanese) Google Scholar
  91. 91.
    Nagahama T, Ando M, Ohbu M et al (2007) A case report of local recurrence of esophageal cancer after chemoradiation successfully treated be placement of tracheal stent. Jpn J Cancer Chemother 34:1985–1987 (in Japanese) Google Scholar
  92. 92.
    Fujita E, Imanishi A, Fujii T et al (2007) A case of esophageal small cell carcinoma. Progress Dig Endosc 71:58–59 (in Japanese) CrossRefGoogle Scholar
  93. 93.
    Yamamoto S, Tsuda H, Sakano T et al (2007) Esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma combined with small cell carcinoma. Pathol Int 57:523–528CrossRefPubMedGoogle Scholar
  94. 94.
    Hashida H, Komuro K, Iwashiro N et al (2007) A long-term recurrence-free survivor after surgery and chemotherapy for small cell carcinoma of the esophagus. J Jpn Surg Assoc 68:1932–1936 (in Japanese) CrossRefGoogle Scholar
  95. 95.
    Ohshino Y, Terashima H, Ougouchi N et al (2007) A case of esophageal small cell carcinoma with Long-term survival for 8.5 years after surgely. Operation 61:1173–1178 (in Japanese) Google Scholar
  96. 96.
    Chin K, Baba S, Hosoka H et al (2008) Irinotecan plus cisplatin for therapy of small-cell carcinoma of the esophagus: Report of 12 cases from single institution experience. Jpn J Clin oncol 38:426–431CrossRefPubMedGoogle Scholar
  97. 97.
    Masuzawa T, Fujitani K, Hirao M et al (2008) A fatal case of small cell type undifferentiated carcinoma of the esophagus with sudden diarrhea and bloody discharge by CPT-11. Jpn J Cancer Chemother 35:1741–1744 (in Japanese) Google Scholar
  98. 98.
    Kaneda K, Nishimura T, Sendo H et al (2008) A case of small cell carcinoma of the esophagus with rapid recurrence after curative resection. J Jpn Surg Assoc 69:1053–1057 (in Japanese) CrossRefGoogle Scholar
  99. 99.
    Yoshii T, Motohashi O, Nishimura K et al (2008) Experiences of salvage EMR for patient with local failure of chemoradiotherapy. Progress Dig Endosc 73:30–35 (in Japanese) CrossRefGoogle Scholar
  100. 100.
    Yamamoto S, Chino O, Shimada H et al (2008) A case of esophageal small cell carcinoma and its difficult in preoperative diagnosis. Progress Dig Endosc 73:132–133 (in Japanese) CrossRefGoogle Scholar
  101. 101.
    Kurokawa D, Yasui Y, Kotake J et al (2008) A case of endocrine cell carcinoma of the esophagus. Aijinkai Med J 40:226–229 (in Japanese) Google Scholar
  102. 102.
    Sano A, Kikuchi J, Kobayashi Y et al (2008) A resected case of endocrine cell carcinoma of the esophagus. Jpn J Gastroenterol Surg 41:1898–1903 (in Japanese) CrossRefGoogle Scholar
  103. 103.
    Haruta S, Ueno M, Udagawa H et al (2009) Treatment process and tumor marker of esophageal cancer: A case of small cell carcinoma of the esophagus with specific histological features. Esophagus 6:139–142Google Scholar
  104. 104.
    Watanabe G, Itami A, Kondo M et al (2009) A difficult-to-diagnosis case of small cell carcinoma with polypoid features that arose in the cervical esophagus. Jpn J Gastroenterol Surg 42:362–367 (in Japanese) CrossRefGoogle Scholar
  105. 105.
    Hirota M, Nakamura E, Yamashita N et al (2009) A case of superficial small cell carcinoma of the esophagus. Jpn J Cancer Chemother 36:1537–1539 (in Japanese) Google Scholar
  106. 106.
    Hatakeyama M, Saito H, Asai M et al (2009) A case of small cell carcinoma of esophagus. J Nayoro City Hosp 17:30–34 (in Japanese) Google Scholar
  107. 107.
    Mizuiri H, Hihara J, Okada M (2009) CDDP + CPT-11 therapy is useful for stage IVb esophagus small cell carcinoma. Jpn J Cancer Chemother 36:831–834 (in Japanese) Google Scholar
  108. 108.
    Nakajima S, Hidaka H, Umekita Y et al (2009) A 4-year survivor of small cell carcinoma of the esophagus with liver metastases managed by multidisciplinary treatment. J Clin Surg 64:1605–1610 (in Japanese) Google Scholar
  109. 109.
    Aoyama T, Saeki H, Fujisawa J et al (2009) A long-term recurrence-free survivor after chemotherapy with 5-FU plus CDDP and surgery for small cell carcinoma of the esophagus. Jpn J Cancer Chemother 36:637–640 (in Japanese) Google Scholar
  110. 110.
    Aizawa R, Takakura K, Kubo Y et al (2009) A case of primary small cell carcinoma of the esophagus responding remarkably to carboplatin (CBDCA) + etoposide (VP-16) combination therapy and radiation therapy. J Jpn Soc Gastroenterol 106:1334–1342 (in Japanese) Google Scholar
  111. 111.
    Kitagawa H, Akimori T, Namikawa T et al (2009) A case of small cell undifferentiated carcinoma of the esophagus successfully treated by chemoradiotherapy. Jpn J Cancer Chemother 36:1737–1739 (in Japanese) Google Scholar
  112. 112.
    Ozawa T, Wachi E (2009) Endocrine cell carcinoma of the esophagus resected by ESD after magnifying endoscopy with narrow band imaging. Gastroenterol Endosc 51:2437–2446 (in Japanese) Google Scholar
  113. 113.
    Atsumi K, Shinoyama Y, Nomoto S et al (2010) Chemoradiation for small cell esophageal carcinoma: report of 11 cases from multi-institution experience. J Radiat Res 51:15–20CrossRefPubMedGoogle Scholar
  114. 114.
    Kubo H, Kijima D, Tada K et al (2010) A case of synchronous endocrine cell carcinoma and squamous cell carcinoma of esophagus. Surgery 72:1225–1228 (in Japanese) Google Scholar
  115. 115.
    Kanzaki M, Muto Y, Yoshinoucih S et al (2010) A case of esophageal small cell carcinoma with syndrome of inappropriate antidiuretic hormone secretion. Jpn J Cancer Chemother 37:1941–1944 (in Japanese) Google Scholar
  116. 116.
    Mizuuchi Y, Anbe K, Yamagata N et al (2010) A case of stage IVb small cell carcinoma of the esophagus obtained prolonged survival after combined modality therapy. Jpn J Cancer Chemother 37:715–718 (in Japanese) Google Scholar
  117. 117.
    Suzuki S, Goto M, Okamato T et al (2010) A case of small cell carcinoma of the esophagus with SIADH. Jpn J Cancer Chemother 37:123–126 (in Japanese) Google Scholar
  118. 118.
    Shibahara H, Yoshida K, Kuze S et al (2010) A case of esophageal small cell carcinoma with survival for 6 years due to resection only against repeated recurrence lymph node. Operation 64:1579–1582 (in Japanese) Google Scholar
  119. 119.
    Suzuki K, Oh K, Yada A et al (2010) A case of undifferentiated small-cell carcinoma of the esophagus. JJCS 35:164–167 (in Japanese) CrossRefGoogle Scholar
  120. 120.
    Isohata N, Naritaka Y, Shimakawa T et al (2010) A case of multiple esophageal cancers with coexisting small-cell and squamous cell carcinoma. JJCS 35:158–163 (in Japanese) CrossRefGoogle Scholar
  121. 121.
    Matsui S, Harasawa S, Ban S (2010) A case of esophageal small cell carcinoma for which chemotherapy (etoposide + carboplatin) was effective. Progress Dig Endosc 76:54–55 (in Japanese) CrossRefGoogle Scholar
  122. 122.
    Kanamori J, Shiomi M, Sekoguchi E et al (2011) A case of superficial small cell carcinoma of the esophagus. Surgery 73:299–302 (in Japanese) Google Scholar
  123. 123.
    Asama H, Wakatsuki T, Asano T et al (2011) A case of endocrine cell carcinoma of the esophagus with remarkable response of combination chemotherapy with CPT-11 and CDDP. Fukushima Med J 61:88–94 (in Japanese) Google Scholar
  124. 124.
    Murakami K, Akutsu Y, Miyazawa Y et al (2011) A case of small-cell esophageal cancer with chronic renal failure undergoing hemodialysis safely treated with cisplatin and etoposide. Esophagus 8:209–215CrossRefPubMedPubMedCentralGoogle Scholar
  125. 125.
    Kato K, Chiba T, Oyama K et al (2011) A case of neuroendocrine carcinoma of esophagus with a remarkable to chemo-radiotherapy. Jpn J Cancer Chemother 38:2643–2645 (in Japanese) Google Scholar
  126. 126.
    Ando T, Hosokawa A, Yamawaki H et al (2011) Esophageal small-cell carcinoma with syndrome of inappropriate secretin of antidiuretic hormone. Intern Med 50:1099–1103CrossRefPubMedGoogle Scholar
  127. 127.
    Kudoh K, Doi K, Ogata K et al (2011) A case of small cell carcinoma of esophagus treated by chemotherapy with CDDP plus CPT-11 and radiotherapy. Jpn J Cancer Chemother 37:2403–2405 (in Japanese) Google Scholar
  128. 128.
    Fujimoto C, Nakaya M, Oonuki Y et al (2011) Thyroid metastasis of esophageal small cell carcinoma. Otolaryngology-Head Neck Surg 83:333–336 (in Japanese) Google Scholar
  129. 129.
    Kobayashi K, Aoki T, Nishioka K et al (2011) A case of esophageal endocrine cell carcinoma that recurred in the lymph nodes around the thoracic aorta after ESD. Gastroenterological Endoscopy 53:28–34 (in Japanese) Google Scholar
  130. 130.
    Tanizaki K, Kobayashi K, Takachi K et al (2011) A case report of long-term survival of endocrine cell carcinoma of the esophagus with chemo-radiation therapy. Jpn J Cancer Chemother 38:2391–2393 (in Japanese) Google Scholar
  131. 131.
    Tokunaga N, Itaba S, Nakamura K et al (2012) A case of lymph node metastasis from esophageal small-cell-type endocrine cell carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration. J Jpn Soc Gastroenterol 109:1360–1366 (in Japanese) Google Scholar
  132. 132.
    Murasse T, Higurashi T, Akatsuka S et al (2012) A case of endocrine cell carcinoma of the esophagus successfully treated by chemoradiotherapy. Jpn J Cancer Chemother 39:111–113 (in Japan) Google Scholar
  133. 133.
    Matsumori T, Murakami S, Araki O et al (2012) A case report of primary small cell esophageal carcinoma responding successfully to radiochemotherapy. Jpn J Cancer Chemother 39:1119–1121 (in Japanese) Google Scholar
  134. 134.
    Kasuga A, Naruge D, Arima S et al (2012) A case of simultaneous double cancer of esophageal neuroendocrine carcinoma and squamous cell carcinoma of the lung with chest wall invasion. Clin Oncol 10:572–577 (in Japanese) Google Scholar
  135. 135.
    Isshiki H, Satou S, Yajima H et al (2012) A case of esophageal endocrine cell carcinoma with multiple liver metastases that had a complete response to multidisciplinary therapy. J Jpn Soc Gastroenterol 109:1902–1909 (in Japanese) Google Scholar
  136. 136.
    Nishimura M, Kaiho T, Yanagisawa S et al (2012) A case of recurrent hepatic resection after surgery for esophageal cancer with neuroendocrine component. Jpn J Gastroenterol Surg 45:359–368 (in Japanese) CrossRefGoogle Scholar
  137. 137.
    Kanazawa N, Mashima H, Jin M et al (2013) A case of metachronous esophageal cancer of small cell and squamous cell carcinoma. Gastroenterol Endosc 55:1986–1994 (in Japanese) Google Scholar
  138. 138.
    Takeoka T, Hirao M, Fujitani K et al (2013) A case of neuroendocrine cell carcinoma of the esophagus with lung metastases successfully treated with CPT-11/CDDP. Jpn J Cancer Chemother 40:2121–2123 (in Japanese) Google Scholar
  139. 139.
    Takeuchi D, Koike N, Okumura M et al (2013) A case of small cell neuroendocrine carcinoma of the esophagus after radiotherapy for breast cancer. Jpn J Gastroenterol Surg 46:401–408 (in Japanese) CrossRefGoogle Scholar
  140. 140.
    Nishiguchi Y, Tanaka T, Takayama T et al (2013) A case of large cell endocrine cell carcinoma of the esophagus. J Jpn Surg Assoc 74:2446–2452 (in Japanese) CrossRefGoogle Scholar
  141. 141.
    Nagasaki E, Yuda M, Tanishima Y et al (2013) Complete response of esophageal small cell carcinoma amrubicin treatment. J Infect Chemother 19:770–775CrossRefPubMedGoogle Scholar
  142. 142.
    Mochitsuki N, Kobayashi M, Nishioji K et al (2013) A case of esophageal endocrine cell carcinoma detected by esophagogastroduodenoscopy during a health check-up. J Gastrointest Cancer Screen 51:557–563 (in Japanese) Google Scholar
  143. 143.
    Mita Y, Hoshino I, Toyozumi T et al (2013) A case of esophageal endocrine cell carcinoma with a remarkable response to neoadjuvant chemotherapy. J Jpn Surg Assoc 74:380–385 (in Japanese) CrossRefGoogle Scholar
  144. 144.
    Watanabe K, Hikichi T, Sato M et al (2014) A case of endocrine cell carcinoma combined with squamous cell carcinoma of the esophagus resected be endoscopic submucosal dissection. Fukushima J Med Sci 60:187–191CrossRefPubMedGoogle Scholar
  145. 145.
    Maeda N, Shirakawa Y, Koujima T et al (2014) Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil. Journal of Okayama Med Assoc 126:39–43 (in Japanese) Google Scholar
  146. 146.
    Urabe K, Tahara K, Hotei H et al (2014) A case of endocrine cell carcinoma (small cell type) of the esophagus which was combined and diagnosed squamous cell carcinoma before operation. Surgery 76:421–424 (in Japanese) Google Scholar
  147. 147.
    Tomiyasu T, Maeda H, Nagano H et al (2014) A case of esophageal cancer combined with small cell carcinoma and squamous cell carcinoma. Jpn J Clin Exp Med 91:108–114 (in Japanese) Google Scholar
  148. 148.
    Akagi I, Miyashita M, Makino H et al (2014) Small cell carcinoma of the esophagus: A case report. J Nippon Med Sch 81:97–100CrossRefPubMedGoogle Scholar
  149. 149.
    Yamakoshi Y, Kubo N, Ohira M et al (2014) Stage IV small cell esophageal carcinoma that responded to various chemotherapeutic regimens with relative longevity: a case report. Jpn J Cancer Chemother 41:2021–2023 (in Japanese) Google Scholar
  150. 150.
    Terashima T, Sudo T, Kakuta T et al (2014) A case of superficial endocrine cell carcinoma of esophagus with long-term recurrence-free survival after surgery. Niigata Med J 129:274–280 (in Japanese) Google Scholar
  151. 151.
    Saito R, Harata TJ, Mizuno Y et al (2015) A case of small cell carcinoma of the esophagus with skin metastasis. J Hiroshima Med Ass 68:270–273 (in Japanese) Google Scholar
  152. 152.
    Yamada K, Saito H, Kondo T et al (2015) Multicenter phase II study of nedaplatin and irinotecan for patients with squamous cell carcinoma of the lung: Thoracic Oncology Research Group 0910. Anticancer Res 35:6705–6712PubMedGoogle Scholar
  153. 153.
    Han J-Y, Lee DH, Lee SY et al (2005) Phase II study of weekly irinotecan plus capecitabine for chemotherapy-naive patients with advanced non-small cell lung carcinoma. Cancer 104:2759–2765CrossRefPubMedGoogle Scholar
  154. 154.
    Ohe Y, Ohashi Y, Kubota K et al (2007) Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol 18:317–323CrossRefPubMedGoogle Scholar
  155. 155.
    Noda K, Nishiwaki Y, Kawahara M, Japan Clinical Oncology Group et al (2002) Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med 346:85–91CrossRefPubMedGoogle Scholar
  156. 156.
    Lara PN Jr, Natale R, Crowley J et al (2009) Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124. J Clin Oncol 27:2530–2535CrossRefPubMedPubMedCentralGoogle Scholar
  157. 157.
    Mitry E, Baudin E, Ducreux M et al (1999) Treatment of poorly differentiated neuroendocrine tumors with etoposide and cisplatin. Br J Cancer 81:1351–1355CrossRefPubMedPubMedCentralGoogle Scholar
  158. 158.
    Yamaguchi T, Machida N, Morizane C et al (2014) Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system. Cancer Sci 105:1176–1181CrossRefPubMedPubMedCentralGoogle Scholar
  159. 159.
    Yamada M, Kudoh S, Hirata K et al (1998) Risk factors of pneumonitis following chemoradiotherapy for lung cancer. 34:71–75Google Scholar
  160. 160.
    Japan Esophageal Society (2016) Guidelines for diagnosis and treatment of carcinoma of the lung. Kanehara, Tokyo (in Japanese) Google Scholar
  161. 161.
    von Pawel J, Jotte R, Spigel DR et al (2014) Randomized phase III trial of amrubicin versus topotecan as second-line treatment for patients with small-cell lung cancer. J Clin Oncol 32:4012–4019CrossRefGoogle Scholar

Copyright information

© The Japan Society of Clinical Oncology 2019

Authors and Affiliations

  1. 1.Division of Gastroenterology and Hepatology, Department of Internal Medicine (Omori)Toho UniversityTokyoJapan
  2. 2.Department of Clinical Oncology, Toho University Graduate School of MedicineToho UniversityTokyoJapan
  3. 3.Department of Surgery, School of MedicineToho UniversityTokyoJapan

Personalised recommendations