Update on Tildrakizumab for Psoriasis

  • Abdul R. AnsariEmail author
  • Arjun M. Bashyam
  • Steven R. Feldman
Psoriasis (J Wu, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Psoriasis


Purpose of Review

Tildrakizumab, a humanized IgG1κ monoclonal antibody that inhibits the p19 subunit of interleukin (IL-)23, is FDA approved for the treatment of moderate-to-severe plaque psoriasis. This article will review recent publications on tildrakizumab to evaluate its pharmacokinetics, efficacy, and safety.

Recent Findings

Tildrakizumab maintains efficacy in moderate-to-severe plaque psoriasis for up to 3 years with low risk of adverse events.


IL-23p19 inhibition with tildrakizumab is a useful therapy for treating moderate-to-severe psoriasis. It is superior to placebo and etanercept in clinical trials as measured by Psoriasis Area Severity Index (PASI), Physician Global Assessment (PGA), and Dermatology Life Quality Index (DLQI) scores. Clinical improvements are maintained for up to 3 years. It has a low frequency of adverse events that is similar to placebo, with the most common being headache and nasopharyngitis. Tildrakizumab can be a useful therapeutic option for patients with plaque psoriasis resistant to phototherapy and other systemic medications.


Tildrakizumab Ilumya IL23p19 Efficacy Safety Long term 


Compliance with Ethical Standards

Conflict of Interest

Steven Feldman has received research, speaking, and/or consulting support from a variety of companies including Galderma, GSK/Stiefel, Almirall, Leo Pharma, Boehringer Ingelheim, Mylan, Celgene, Pfizer, Valeant, Abbvie, Samsung, Janssen, Lilly, Menlo, Merck, Novartis, Regeneron, Sanofi, Novan, Qurient, National Biological Corporation, Caremark, Advance Medical, Sun Pharma, Suncare Research, Informa, UpToDate, and National Psoriasis Foundation. He is founder and majority owner of and founder and part owner of Causa Research, a company dedicated to enhancing patients’ adherence to treatment.

Abdul Ansari and Arjun Bashyam have no conflicts to disclose.

Human and Animal Rights

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Center for Dermatology Research, Department of DermatologyWake Forest School of MedicineWinston-SalemUSA
  2. 2.Department of PathologyWake Forest School of MedicineWinston-SalemUSA
  3. 3.Department of Social Sciences & Health PolicyWake Forest School of MedicineWinston-SalemUSA
  4. 4.Department of DermatologyUniversity of Southern DenmarkOdenseDenmark

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