Fertility-Sparing Treatment Options in Young Patients with Early-Stage Endometrial Cancer

  • Eray Çalışkan
  • Cihan KaradağEmail author
Endometrial Cancer (G. Sel, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Endometrial Cancer
  2. Topical Collection on Endometrial Cancer


Purpose of Review

To summarize fertility-sparing treatment options in young patients with early-stage endometrial cancer.

Recent Findings

A levonorgestrel-releasing intrauterine device combined with oral progestins seems more effective for patients with endometrial cancer and desiring fertility. Assisted reproductive techniques seem more effective in achieving pregnancy in these young cancer patients than natural conception.


Endometrial cancer is the most common gynecologic cancer in developed countries. For younger patients who wish to have children, fertility preservation methods are available, but not always reasonable in an individual patient. Furthermore, fertility-preserving treatment has some risks with regard to surgical effectivity. The main criteria for fertility-sparing treatment are reproductive age of the patient, fertility desire, a grade 1 well-differentiated tumor, diagnosis should be performed through D&C, stage 1A tumor with no evidence of myometrial invasion on MRI, and no suspicious adnexal mass. A levonorgestrel-releasing intrauterine device combined with oral progestins seems more effective than using oral progestins alone. D&C should be performed every 3 months after the start of progestin therapy. Patients with two negative endometrial D&C results are considered to have a complete response and eligible for pregnancy. Hysteroscopic resection can be used in patients with grade 1 stage 1 endometrial carcinoma who did not respond to progestin treatment.


Assisted reproductive techniques Endometrial carcinoma Fertility agents, female, hormonal Hysteroscopic surgery Ovarian cancer 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyOkan University School of MedicineİstanbulTurkey

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