Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms

  • Manami InoueEmail author
  • Shoichiro Tsugane
Cancer (MF Leitzmann, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cancer


Purpose of Review

We reviewed the available literature on observational studies, meta-analyses, expert reports, and umbrella reviews. Here, we summarize the latest findings on the association between coffee intake and liver cancer risk.

Recent Findings

Most observational studies and meta-analyses show a protective effect of coffee intake on liver cancer risk, with dose-responsiveness and across different populations, and regardless of hepatitis virus infection status. Risk reduction by coffee consumption has also been observed for chronic liver diseases. Potential mechanisms include the effect of a number of bioactive compounds such as caffeine, chlorogenic acids, phenolic compounds and diterpenes; antioxidant properties; induction of defense mechanisms; and anti-inflammatory properties. Other potential mechanisms include improvement in insulin sensitivity and prevention of metabolic syndrome and diabetes.


Accumulated evidence, with consistency across study designs and populations, suggests that coffee intake probably reduces the risk of liver cancer. Future research should aim to elucidate the mechanism of this preventive effect with establishing the causality of an association.


Coffee Liver cancer Epidemiology Reduced risk Dose-response Mechanism Causality 


Compliance with Ethical Standards

Conflict of Interest

Manami Inoue and Shoichiro Tsugane declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Prevention, Center for Public Health SciencesNational Cancer CenterTokyoJapan
  2. 2.Center for Public Health SciencesNational Cancer CenterTokyoJapan

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