The Endocrine Role of Bone in Cardiometabolic Health

  • Rosemary DeLuccia
  • May Cheung
  • Rohit Ramadoss
  • Abeer Aljahdali
  • Deeptha SukumarEmail author
Cardiovascular Disease (JHY Wu, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cardiovascular Disease


Purpose of Review

The purpose of this review is to discuss the current knowledge about major bone regulating hormones vitamin D, parathyroid hormone (PTH), estrogen and bone metabolism markers osteocalcin (OC), bone-specific alkaline phosphatase (BAP), N-terminal propeptide of type 1 collagen (P1NP), and c-terminal type 1 collagen (CTX) and their mechanistic effects on cardiometabolic health.

Recent Findings

Bone regulating hormones, nutrients, and turnover markers influence different aspects of cardiometabolic health including body composition, cardiovascular function, and glycemic control. While most observational research supports a relationship between bone as an endocrine organ and cardiometabolic outcomes, there are limited human clinical trials to strengthen a causal link between the two.


While the associations between bone and cardiometabolic health are beginning to be understood based on findings from large observations studies, further exploration of bone’s causal influence on health outcomes in humans and the underlying mechanisms of effect are necessary.


Bone Cardiometabolic health Bone turnover Body composition Glycemic control Cardiovascular disease 


Funding Information

No funding or sponsorship was received for this paper.

Compliance with Ethical Standards

Conflict of Interest

Rosemary DeLuccia, May Cheung, Rohit Ramadoss, Abeer Aljahdali, and Deeptha Sukumar declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Rosemary DeLuccia
    • 1
  • May Cheung
    • 1
  • Rohit Ramadoss
    • 1
  • Abeer Aljahdali
    • 1
  • Deeptha Sukumar
    • 1
    Email author
  1. 1.Nutrition Sciences DepartmentDrexel UniversityPhiladelphiaUSA

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