Samenvatting
Niercelcarcinoom is de meest voorkomende maligniteit van de nier. In 4-10% van de gevallen is er sprake van trombusingroei via de vena renalis in de vena cava inferior, in 1% tot in het rechter atrium. Symptomen kunnen hematurie of flankpijn zijn, maar zijn vaak atypisch of helemaal afwezig. In deze klinische les illustreren wij de verschillende presentaties van patiënten met niercelcarcinoom en tumortrombus in de vena cava. We benadrukken de noodzaak tot zorgvuldige preoperatieve planning, waarbij de uroloog, vaatchirurg en cardiothoracaal chirurg in nauw teamverband samen dienen te werken.
Summary
Case reports. Renal cell carcinoma with tumorthrombus in caval vein and right atrium
Renal cell carcinoma is the most common renal malignancy. Thrombus can grow into the renal vein and the caval vein in 4-10% of the cases, and even into the right atrium in 1%. Symptoms are haematuria and/or flank tenderness, although most symptoms are atypical or absent. In this clinical lesson we illustrate the various presentations of patients with renal cell carcinoma and central venous thrombus. We also emphasize the need of a careful pre-operative planning, in which the urologist, surgeon and cardiothoracic surgeon have to cooperate.
Literatuur
Nederlandse Kankerregistratie, www.iknl.nl.
Mellemgaard A, Engholm G, McLaughlin JK, Olsen JH. Risk factors for renal cell carcinoma in Denmark. I. Role of socioeconomic status, tobacco use, beverages, and family history. Cancer Causes Control. 1994 Mar;5(2):105-13.
Cotran RS, Kumar V, Collins T. Robbins pathologic basis of disease. 6th ed. Philadelphia: W.B. Saunders Company. 1999.
Wotkowicz C, Wszolek MF, Libertino JA. Resection of renal tumors invading the vena cava. Urol Clin N Am. 2008;35:657-71.
Motzer RJ, Mazumdar M, Bacik J, Berg W, et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 1999 Aug;17(8):2530-40.
Nesbitt JC, Soltero ER, Dinney CPN, et al. Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus. Ann Thorac Surg. 1997;63:1592-600.
Miyake H, Terakawa T, Furukawa J, et al. Prognostic significance of tumor extension into venous system in patients undergoing surgical treatment for renal cell carcinoma with venous tumor thrombus. EJSO. 2012;38(7):630-6.
Flanigan RC, Salmon SE, Blumenstein BA, et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med. 2001;345(23):1655-9.
Coppin C, Kollmannsberger C, Le L, et al. Targeted therapy for advanced renal cell cancer (RCC): a Cochrane systematic review of published randomised trials. BJU Int. 2011 Nov;108(10):1556-63.
Bex A, Blank C, Meinhardt W, et al. A phase II study of presurgical sunitinib in patients with metastatic clear-cell renal carcinoma and the primary tumor in situ. Urology. 2011 Oct;78(4):832-7.
Author information
Authors and Affiliations
Corresponding author
Additional information
* drs. J.G.H. Poerink, afdeling Urologie, nu werkzaam op afdeling Chirurgie, Martini Ziekenhuis, Groningen
dr. G.S.C. Geuzebroek, afdeling Vaatchirurgie
drs. K.W.H. Gisolf, afdeling Urologie
drs. T.L. de Kroon, afdeling Cardiothoracale chirurgie
drs. R.H.W. van de Mortel, afdeling Vaatchirurgie
dr. J. Wille, afdeling Vaatchirurgie
Alle auteurs zijn verbonden aan het St. Antonius ziekenhuis, Nieuwegein.
Rights and permissions
About this article
Cite this article
Poerink, J., Geuzebroek, G., Gisolf, K. et al. Case reports. Niercelcarcinoom met tumortrombus in vena cava en rechter atrium. Tijdschrift voor Urologie 4, 125–129 (2014). https://doi.org/10.1007/s13629-014-0066-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13629-014-0066-8