MicroRNA-30e inhibits proliferation and invasion of non-small cell lung cancer via targeting SOX9
Previous studies have reported that microRNA-30e (miR-30e) is dysregulated in multiple human cancers. However, the expression, functions and molecular mechanism of miR-30e in NSCLC remain unknown. In this study, we found that miR-30e was expressed at a low level in NSCLC tissues and cell lines. In NSCLC cell lines, enforced expression of miR-30e could inhibit cell proliferation and invasion in vitro. In addition, miR-30e negatively regulated SOX9 expression through directly binding to the 3′UTR of SOX9, and an inverse correlation was found between miR-30e and SOX9 mRNA expression in NSCLC tissues. Moreover, knockdown of SOX9 led to decreased proliferation and invasion of NSCLC cells. Taken together, miR-30e acts as a tumor suppressor in NSCLC, and inhibits cell proliferation and invasion possibly by directly targeting SOX9. These findings might provide novel therapeutic targets for NSCLC.
KeywordsMicroRNA-30e Proliferation Invasion SOX9 Non-small cell lung cancer
This work was supported by a grant from the National Nature Science Foundation of China (181774078, 81773453, 81803886), National Nature Science Foundation of Liaoning Province, China (201602227, 20170540300).
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Conflict of interest
All the authors declared no conflicts of interest in this work.
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