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Journal of Radiation Oncology

, Volume 8, Issue 3, pp 349–353 | Cite as

Patterns of relapse in older women diagnosed with estrogen receptor (ER)–positive early-stage breast cancer (BC) treated with lumpectomy without adjuvant endocrine therapy (ET)

  • Manjeet ChadhaEmail author
  • T. Shao
  • S. Cate
  • S. Malamud
  • C. White
  • S. K. Boolbol
Original Research
  • 17 Downloads

Abstract

Purpose

Randomized trials comparing endocrine therapy (ET) with no ET show reduced overall relapse rates with adjuvant ET for patients with early-stage estrogen receptor (ER)–positive breast cancer (BC). Of note, these studies include few patients over the age of 65 years. Currently, with ET routinely prescribed, there is limited opportunity to study the patterns of relapse without ET. The objective of our study is to evaluate the rates of local-regional and distant relapse in older BC women who postoperatively did not receive ET.

Methods

In this retrospective study, we identified 92 patients who did not receive ET after lumpectomy in our database of 1172 patients’ age 65 years or older (median age 75 years) with ER-positive, node-negative BC. Following lumpectomy, 37 patients (40%) received radiation therapy (RT) and 55 patients (60%) were observed.

Results

Median follow-up for the entire cohort is 65.5 months, and the 5-year overall survival rate is 89.3%. The 5-year relapse-free survival rates with lumpectomy + RT and lumpectomy alone are 97% and 84%, respectively (p = 0.008). One of 37 patients treated with lumpectomy + RT developed a local recurrence (3%), and no distant relapse was observed. Among patients treated with lumpectomy alone, 8/55 (15%) had a local relapse and one patient (2%) experienced distant relapse.

Conclusion

Patterns of relapse in older women with ER-positive early-stage BC note that local relapse is the most common site of failure. In this study, we also observed a low risk of distant relapse among patients not receiving ET. These observations on relapse patterns suggest that older women with early-stage BC may derive more benefit from adjuvant RT alone and be spared the potential side effects of ET.

Keywords

Early-stage breast cancer Lumpectomy Older women Endocrine therapy Antiestrogen therapy Breast radiation 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

Not applicable

Informed consent

All co-authors gave their informed consent prior to their inclusion in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Manjeet Chadha
    • 1
    Email author
  • T. Shao
    • 2
  • S. Cate
    • 3
  • S. Malamud
    • 2
  • C. White
    • 1
  • S. K. Boolbol
    • 3
  1. 1.Department of Radiation OncologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Department of MedicineIcahn School of Medicine at Mount SinaiNew YorkUSA
  3. 3.Department of SurgeryIcahn School of Medicine at Mount SinaiNew YorkUSA

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