Sneak peek of Hypericum perforatum L.: phytochemistry, phytochemical efficacy and biotechnological interventions

  • Mohammad Yaseen MirEmail author
  • Saima Hamid
  • Azra N. Kamili
  • Qazi P. Hassan
Review Article


The phytochemistry of Hypericum perforatum (St. John’s wort) has been elaborated extensively owing to its immense application in medicinal chemistry. Illustrated pharmacological activities like antidepressant, antiviral, and antibacterial effects demonstrated its substantiation for numerous of the conventional purposes reported for St John’s wort. St. John’s wort is herbal remedy extensively used in mild to moderate depression. Most of pharmacological activities were assigned to presence of photosensitive naphthodianthrone; hypericin and other allied flavonoid constituents. Escalating demands of hyperforin as antidepressant added more lure to H. perforatum L. The crude extracts of H. perforatum containing phloroglucinols were used for free radical scavenging and against DNA damage. To meet increasing demands of this drug, researchers need to tailor out the biosynthetic pathways to improve secondary metabolite. This necessitated advancement in biotechnological intervention to improve phytochemical potential of this growing herb. This review will brief out ecology, chemistry and phytochemical efficacy with respective phytoconstituents. Further, review will emphasize biotechnological interventions including both conventional and modern contrivances that have been implemented to augment the glory of this species.


Phytochemistry Phytochemical efficacy Naphthodianthrones Phloroglucinols 







Photodynamic therapy


Chalcone synthase




Monoamine oxidase


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interests.


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© Society for Plant Biochemistry and Biotechnology 2019

Authors and Affiliations

  • Mohammad Yaseen Mir
    • 1
    Email author
  • Saima Hamid
    • 1
  • Azra N. Kamili
    • 1
  • Qazi P. Hassan
    • 2
  1. 1.P.G. Department of Environmental Science/Centre of Research for DevelopmentUniversity of KashmirSrinagarIndia
  2. 2.Indian Institute of Integrative Medicine (CSIR)Sanat Nagar, SrinagarIndia

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