Brazilian Journal of Physics

, Volume 43, Issue 4, pp 268–280 | Cite as

Physics and Its Interfaces with Medicinal Chemistry and Drug Design

  • Ricardo N. Santos
  • Adriano D. AndricopuloEmail author
General and Applied Physics


Medicinal chemistry is a multidisciplinary subject that integrates knowledge from a variety of fields of science, including, but not limited to, chemistry, biology, and physics. The area of drug design involves the cooperative work of scientists with a diverse range of backgrounds and technical skills, trying to tackle complex problems using an integration of approaches and methods. One important contribution to this field comes from physics through studies that attempt to identify and quantify the molecular interactions between small molecules (drugs) and biological targets (receptors), such as the forces that govern the interactions, the thermodynamics of the drug–receptor interactions, and so on. In this context, the interfaces of physics, medicinal chemistry, and drug design are of vital importance for the development of drugs that not only have the right chemistry but also the right intermolecular properties to interact at the macromolecular level, providing useful information about the principles and molecular mechanisms underlying the therapeutic action of drugs. This article highlights some of the most important connections between physics and medicinal chemistry in the design of new drugs.


Medicinal chemistry Physics Drug design Molecular interactions 



We thank the São Carlos Institute of Physics (Instituto de Física de São Carlos) for providing an interesting and unique interdisciplinary research environment in the area of medicinal chemistry and drug design.

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Copyright information

© Sociedade Brasileira de Física 2013

Authors and Affiliations

  1. 1.Instituto de Física de São CarlosUniversidade de São PauloSão CarlosBrazil

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