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Biomedical Engineering Letters

, Volume 9, Issue 3, pp 351–358 | Cite as

Applications of photobiomodulation in hearing research: from bench to clinic

  • Jae-Hun Lee
  • Sehwan Kim
  • Jae Yun Jung
  • Min Young LeeEmail author
Review Article

Abstract

Hearing loss is very common and economically burdensome. No accepted therapeutic modality for sensorineural hearing loss is yet available; most clinicians emphasize rehabilitation, placing hearing aids and cochlear implants. Photobiomodulation (PBM) employs light energy to enhance or modulate the activities of specific organs, and is a popular non-invasive therapy used to treat skin lesions and neurodegenerative disorders. Efforts to use PBM to improve hearing have been ongoing for several decades. Initial in vitro studies using cell lines and ex vivo culture techniques have now been supplanted by in vivo studies in animals; PBM protects the sensory epithelium and triggers neural regeneration. Many reports have used PBM to treat tinnitus. In this brief review, we introduce PBM applications in hearing research, helpful protocols, and relevant background literature.

Keywords

Photobiomodulation Low-level laser therapy Hearing loss 

Notes

Acknowledgements

This study was supported by the Ministry of Science, Information and Communications technology (ICT) and Future Planning grant funded by the Korean Government (NRF-2017R1D1A1B03033219), and supported by the Ministry of Science, Information and Communications technology (ICT) and Future Planning grant funded by the Korean Government (NRF-2016R1D1A1B03932624).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Adams PF, Hendershot GE, Marano MA. Current estimates from the National Health Interview Survey, 1996. Vital Health Stat. 1999;10(200):1–203.Google Scholar
  2. 2.
    Moscicki EK, et al. Hearing loss in the elderly: an epidemiologic study of the Framingham Heart Study Cohort. Ear Hear. 1985;6(4):184–90.Google Scholar
  3. 3.
    Cooper JC Jr, Gates GA. Hearing in the elderly–the Framingham cohort, 1983–1985: part II. Prevalence of central auditory processing disorders. Ear Hear. 1991;12(5):304–11.Google Scholar
  4. 4.
    Cruickshanks KJ, et al. Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The epidemiology of hearing loss study. Am J Epidemiol. 1998;148(9):879–86.Google Scholar
  5. 5.
    Agrawal Y, Platz EA, Niparko JK. Prevalence of hearing loss and differences by demographic characteristics among US adults: data from the National Health and Nutrition Examination Survey, 1999–2004. Arch Intern Med. 2008;168(14):1522–30.Google Scholar
  6. 6.
    Wallhagen MI, et al. An increasing prevalence of hearing impairment and associated risk factors over three decades of the Alameda County Study. Am J Public Health. 1997;87(3):440–2.Google Scholar
  7. 7.
    Dalton DS, et al. The impact of hearing loss on quality of life in older adults. Gerontologist. 2003;43(5):661–8.Google Scholar
  8. 8.
    Tantawy SA, et al. Laser photobiomodulation is more effective than ultrasound therapy in patients with chronic nonspecific low back pain: a comparative study. Lasers Med Sci. 2019;34(4):793–800.Google Scholar
  9. 9.
    Akerzoul N, Chbicheb S. Low laser therapy as an effective treatment of recurrent aphtous ulcers: a clinical case reporting two locations. Pan Afr Med J. 2018;30:205.Google Scholar
  10. 10.
    de Andrade ALM, et al. Effect of photobiomodulation therapy (808 nm) in the control of neuropathic pain in mice. Lasers Med Sci. 2017;32(4):865–72.Google Scholar
  11. 11.
    Reddy GK, Stehno-Bittel L, Enwemeka CS. Laser photostimulation of collagen production in healing rabbit Achilles tendons. Las Surg Med Off J Am Soc Laser Med Surg. 1998;22(5):281–7.Google Scholar
  12. 12.
    da-Palma-Cruz M, et al. Photobiomodulation modulates the resolution of inflammation during acute lung injury induced by sepsis. Lasers Med Sci. 2019;34(1):191–9.Google Scholar
  13. 13.
    Kaneguchi A, et al. Low-level laser therapy prevents treadmill exercise-induced progression of arthrogenic joint contracture via attenuation of inflammation and fibrosis in remobilized rat knees. Inflammation. 2018;1–17.Google Scholar
  14. 14.
    Lee KTD, et al. The effect of low-level laser irradiation on hyperglycemia-induced inflammation in human gingival fibroblasts. Lasers Med Sci. 2018;1–8.Google Scholar
  15. 15.
    Nomura K, Yamaguchi M, Abiko Y. Inhibition of interleukin-1beta production and gene expression in human gingival fibroblasts by low-energy laser irradiation. Lasers Med Sci. 2001;16(3):218–23.Google Scholar
  16. 16.
    Traverzim M, et al. Effect of led photobiomodulation on analgesia during labor: study protocol for a randomized clinical trial. Medicine (Baltimore). 2018;97(25):e11120.Google Scholar
  17. 17.
    Chung H, et al. The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng. 2012;40(2):516–33.Google Scholar
  18. 18.
    Martignago CCS, et al. Comparison of two different laser photobiomodulation protocols on the viability of random skin flap in rats. Lasers Med Sci. 2018;1–7.Google Scholar
  19. 19.
    Mokoena D, et al. Role of photobiomodulation on the activation of the Smad pathway via TGF-beta in wound healing. J Photochem Photobiol B. 2018;189:138–44.Google Scholar
  20. 20.
    Buchaim RL, et al. Effect of low-level laser therapy (LLLT) on peripheral nerve regeneration using fibrin glue derived from snake venom. Injury. 2015;46(4):655–60.Google Scholar
  21. 21.
    Buchaim DV, et al. The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve. Lasers Med Sci. 2016;31(5):965–72.Google Scholar
  22. 22.
    Caruso-Davis MK, et al. Efficacy of low-level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011;21(6):722–9.Google Scholar
  23. 23.
    Pickles JO, Comis SD, Osborne MP. Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction. Hear Res. 1984;15(2):103–12.Google Scholar
  24. 24.
    Assad JA, Hacohen N, Corey DP. Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells. Proc Natl Acad Sci USA. 1989;86(8):2918–22.Google Scholar
  25. 25.
    Keen EC, Hudspeth AJ. Transfer characteristics of the hair cell’s afferent synapse. Proc Natl Acad Sci USA. 2006;103(14):5537–42.Google Scholar
  26. 26.
    Goutman JD, Glowatzki E. Time course and calcium dependence of transmitter release at a single ribbon synapse. Proc Natl Acad Sci USA. 2007;104(41):16341–6.Google Scholar
  27. 27.
    Wang Y, Hirose K, Liberman MC. Dynamics of noise-induced cellular injury and repair in the mouse cochlea. J Assoc Res Otolaryngol. 2002;3(3):248–68.Google Scholar
  28. 28.
    Chen GD. Prestin gene expression in the rat cochlea following intense noise exposure. Hear Res. 2006;222(1–2):54–61.Google Scholar
  29. 29.
    Chen GD, Zhao HB. Effects of intense noise exposure on the outer hair cell plasma membrane fluidity. Hear Res. 2007;226(1–2):14–21.Google Scholar
  30. 30.
    Puel JL, et al. Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss. NeuroReport. 1998;9(9):2109–14.Google Scholar
  31. 31.
    Huth ME, Ricci AJ, Cheng AG. Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection. Int J Otolaryngol. 2011;2011:937861.Google Scholar
  32. 32.
    Warchol ME. Cellular mechanisms of aminoglycoside ototoxicity. Curr Opin Otolaryngol Head Neck Surg. 2010;18(5):454–8.Google Scholar
  33. 33.
    Hirose K, Hockenbery DM, Rubel EW. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res. 1997;104(1–2):1–14.Google Scholar
  34. 34.
    Clerici WJ, et al. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res. 1996;98(1–2):116–24.Google Scholar
  35. 35.
    Jiang H, Sha SH, Schacht J. NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity. J Neurosci Res. 2005;79(5):644–51.Google Scholar
  36. 36.
    Jiang H, Sha SH, Schacht J. Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. J Neurosci Res. 2006;83(8):1544–51.Google Scholar
  37. 37.
    Choung YH, et al. Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin. Neuroscience. 2009;161(1):214–26.Google Scholar
  38. 38.
    Wang J, et al. Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig. Neuropharmacology. 2003;45(3):380–93.Google Scholar
  39. 39.
    Wang J, et al. Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss. Cancer Res. 2004;64(24):9217–24.Google Scholar
  40. 40.
    Kujawa SG, Liberman MC. Adding insult to injury: cochlear nerve degeneration after “temporary” noise-induced hearing loss. J Neurosci. 2009;29(45):14077–85.Google Scholar
  41. 41.
    Sly DJ, et al. Applying neurotrophins to the round window rescues auditory function and reduces inner hair cell synaptopathy after noise-induced hearing loss. Otol Neurotol. 2016;37(9):1223–30.Google Scholar
  42. 42.
    Wan G, et al. Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. Elife. 2014;3:e03564.Google Scholar
  43. 43.
    Suzuki J, Corfas G, Liberman MC. Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure. Sci Rep. 2016;6:24907.Google Scholar
  44. 44.
    Furman AC, Kujawa SG, Liberman MC. Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates. J Neurophysiol. 2013;110(3):577–86.Google Scholar
  45. 45.
    Lee JH, et al. Secondary degeneration of auditory neurons after topical aminoglycoside administration in a Gerbil model. Biomed Res Int. 2018;2018:9158187.Google Scholar
  46. 46.
    Lee MY, et al. Photobiomodulation by laser therapy rescued auditory neuropathy induced by ouabain. Neurosci Lett. 2016;633:165–73.Google Scholar
  47. 47.
    Wan G, Corfas G. Transient auditory nerve demyelination as a new mechanism for hidden hearing loss. Nat Commun. 2017;8:14487.Google Scholar
  48. 48.
    Hewitt PG. Conceptual physics. London: Pearson Educación; 2002.Google Scholar
  49. 49.
    Heiskanen V, Hamblin MR. Photobiomodulation: lasers vs. light emitting diodes? Photochem Photobiol Sci. 2018;17(8):1003–17.Google Scholar
  50. 50.
    Pelaez EA, Villegas ER. LED power reduction trade-offs for ambulatory pulse oximetry. In 29th Annual international conference of the IEEE engineering in medicine and biology society, 2007 (EMBS 2007). IEEE; 2007.Google Scholar
  51. 51.
    de Sousa AP, et al. Effect of LED phototherapy (lambda700 ± 20 nm) on TGF-beta expression during wound healing: an immunohistochemical study in a rodent model. Photomed Laser Surg. 2011;29(9):605–11.Google Scholar
  52. 52.
    Pinheiro AL, et al. Light microscopic description of the effects of laser phototherapy on bone defects grafted with mineral trioxide aggregate, bone morphogenetic proteins, and guided bone regeneration in a rodent model. J Biomed Mater Res A. 2011;98(2):212–21.Google Scholar
  53. 53.
    Oliveira Sampaio SC, et al. Effect of laser and LED phototherapies on the healing of cutaneous wound on healthy and iron-deficient Wistar rats and their impact on fibroblastic activity during wound healing. Lasers Med Sci. 2013;28(3):799–806.Google Scholar
  54. 54.
    Smith KC. The photobiological basis of low level laser radiation therapy. Laser Therapy. 1991;3(1):19–24.Google Scholar
  55. 55.
    Hudson DE, et al. Penetration of laser light at 808 and 980 nm in bovine tissue samples. Photomed Laser Surg. 2013;31(4):163–8.Google Scholar
  56. 56.
    Byrnes KR, et al. Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury. Lasers Surg Med. 2005;36(3):171–85.Google Scholar
  57. 57.
    Tedford CE, et al. Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue. Lasers Surg Med. 2015;47(4):312–22.Google Scholar
  58. 58.
    de Freitas LF, Hamblin MR. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):348–64.Google Scholar
  59. 59.
    Lee J-H, et al. Simultaneous bilateral laser therapy accelerates recovery after noise-induced hearing loss in a rat model. PeerJ. 2016;4:e2252.Google Scholar
  60. 60.
    Lee MY, et al. Treatment of peripheral vestibular dysfunction using photobiomodulation. J Biomed Opt. 2017;22(8):088001.Google Scholar
  61. 61.
    Rhee C-K, et al. Effect of low-level laser treatment on cochlea hair-cell recovery after acute acoustic trauma. J Biomed Opt. 2012;17(6):0680021–6.Google Scholar
  62. 62.
    Rhee C-K, et al. Effect of low-level laser therapy on cochlear hair cell recovery after gentamicin-induced ototoxicity. Lasers Med Sci. 2012;27(5):987–92.Google Scholar
  63. 63.
    Tamura A, et al. Photobiomodulation rescues the cochlea from noise-induced hearing loss via upregulating nuclear factor kappaB expression in rats. Brain Res. 2016;1646:467–74.Google Scholar
  64. 64.
    Moon TH, et al. Safety assessment of trans-tympanic photobiomodulation. Lasers Med Sci. 2016;31(2):323–33.Google Scholar
  65. 65.
    Bartos A, et al. Pre-conditioning with near infrared photobiomodulation reduces inflammatory cytokines and markers of oxidative stress in cochlear hair cells. J Biophotonics. 2016;9(11–12):1125–35.Google Scholar
  66. 66.
    Rhee CK, et al. Effect of low-level laser treatment on cochlea hair-cell recovery after ototoxic hearing loss. J Biomed Opt. 2013;18(12):128003.Google Scholar
  67. 67.
    Chang SY, et al. Photobiomodulation promotes adenoviral gene transduction in auditory cells. Lasers Med Sci. 2018;34(2):367–75.Google Scholar
  68. 68.
    Wu S, et al. Cancer phototherapy via selective photoinactivation of respiratory chain oxidase to trigger a fatal superoxide anion burst. Antioxid Redox Signal. 2014;20(5):733–46.Google Scholar
  69. 69.
    Ferraresi C, et al. Low-level laser (light) therapy increases mitochondrial membrane potential and ATP synthesis in C2C12 myotubes with a peak response at 3–6 h. Photochem Photobiol. 2015;91(2):411–6.Google Scholar
  70. 70.
    Liang H, et al. Photobiomodulation partially rescues visual cortical neurons from cyanide-induced apoptosis. Neuroscience. 2006;139(2):639–49.Google Scholar
  71. 71.
    Wong-Riley MT, et al. Photobiomodulation directly benefits primary neurons functionally inactivated by toxins role of cytochrome c oxidase. J Biol Chem. 2005;280(6):4761–71.Google Scholar
  72. 72.
    Tamura A, et al. Low-level laser therapy for prevention of noise-induced hearing loss in rats. Neurosci Lett. 2015;595:81–6.Google Scholar
  73. 73.
    Partheniadis-Stumpf M, Maurer J, Mann W. Softlasertherapie in Kombination mit Tebonin® iv bei Tinnitus. Laryngorhinootologie. 1993;72(01):28–31.Google Scholar
  74. 74.
    Olivier J, Plath P. Combined low power laser therapy and extracts of Ginkgo biloba in a blind trial of treatment for tinnitus. Laser Therapy. 1993;5(3):137–9.Google Scholar
  75. 75.
    Wedel HV, et al. Soft-laser/ginkgo therapy in chronic tinnitus. In: Rudert H, Werner JA, editors. Lasers in otorhinolaryngology, and in head and neck surgery. Karger Publishers; 1995. p. 105–8.Google Scholar
  76. 76.
    Plath P, Olivier J. Results of combined low-power laser therapy and extracts of Ginkgo biloba in cases of sensorineural hearing loss and tinnitus. In: Rudert H, Werner JA, editors. Lasers in otorhinolaryngology, and in head and neck surgery. Karger Publishers; 1995. p. 101–4.Google Scholar
  77. 77.
    Wilden L, Dindinger D. Treatment of chronic diseases of the inner ear with low level laser therapy (LLLT). Laser Therapy. 1996;8(3):209–12.Google Scholar
  78. 78.
    Mirz F, et al. The low-power laser in the treatment of tinnitus. Clin Otolaryngol Allied Sci. 1999;24(4):346–54.Google Scholar
  79. 79.
    Shiomi Y, et al. Efficacy of transmeatal low power laser irradiation on tinnitus: a preliminary report. Auris Nasus Larynx. 1997;24(1):39–42.Google Scholar
  80. 80.
    Tauber S, et al. Transmeatal cochlear laser (TCL) treatment of cochlear dysfunction: a feasibility study for chronic tinnitus. Lasers Med Sci. 2003;18(3):154–61.Google Scholar
  81. 81.
    Teggi R, et al. Transmeatal low-level laser therapy for chronic tinnitus with cochlear dysfunction. Audiol Neurootol. 2009;14(2):115–20.Google Scholar
  82. 82.
    Salahaldin AH, et al. Low-level laser therapy in patients with complaints of tinnitus: a clinical study. ISRN Otolaryngol. 2012;2012:132060.Google Scholar
  83. 83.
    Cuda D, De Caria A. Effectiveness of combined counseling and low-level laser stimulation in the treatment of disturbing chronic tinnitus. Int Tinnitus J. 2008;14(2):175–80.Google Scholar
  84. 84.
    Gungor A, et al. Effectiveness of transmeatal low power laser irradiation for chronic tinnitus. J Laryngol Otol. 2008;122(5):447–51.Google Scholar
  85. 85.
    Zazzio M. Pain threshold improvement for chronic hyperacusis patients in a prospective clinical study. Photomed Laser Surg. 2010;28(3):371–7.Google Scholar
  86. 86.
    Goodman SS, et al. The effect of low-level laser therapy on hearing. ISRN Otolaryngol. 2013.Google Scholar
  87. 87.
    Okhovat A, et al. Low-level laser for treatment of tinnitus: a self-controlled clinical trial. J Res Med Sci Off J Isfahan Univ Med Sci. 2011;16(1):33.Google Scholar
  88. 88.
    Lane N. Cell biology: power games. Nature. 2006;443(7114):901–3.Google Scholar
  89. 89.
    Albert ES, et al. TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. J Neurophysiol. 2012;107(12):3227–34.Google Scholar
  90. 90.
    Rohacs T. Phosphoinositide regulation of TRP channels. Handb Exp Pharmacol. 2014;223:1143–76.Google Scholar
  91. 91.
    Hardie RC. Photosensitive TRPs. Handb Exp Pharmacol. 2014;223:795–826.Google Scholar
  92. 92.
    Chu J, Wu S, Xing D. Survivin mediates self-protection through ROS/cdc25c/CDK1 signaling pathway during tumor cell apoptosis induced by high fluence low-power laser irradiation. Cancer Lett. 2010;297(2):207–19.Google Scholar
  93. 93.
    Huang YY, et al. Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro. J Biophotonics. 2013;6(10):829–38.Google Scholar
  94. 94.
    Chen AC, et al. Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts. PLoS ONE. 2011;6(7):e22453.Google Scholar

Copyright information

© Korean Society of Medical and Biological Engineering 2019

Authors and Affiliations

  • Jae-Hun Lee
    • 1
    • 2
    • 4
  • Sehwan Kim
    • 1
    • 2
    • 4
  • Jae Yun Jung
    • 1
    • 2
    • 3
    • 4
  • Min Young Lee
    • 1
    • 2
    • 3
    • 4
    Email author
  1. 1.Interdisciplinary Program for Medical LaserDankook UniversityCheonanSouth Korea
  2. 2.Beckman Laser Institute KoreaDankook UniversityCheonanSouth Korea
  3. 3.Department of Otolaryngology Head and Neck SurgeryDankook University HospitalCheonanSouth Korea
  4. 4.College of MedicineDankook UniversityCheonanSouth Korea

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