Effect of prenatal zinc supplementation on adipose tissue-derived hormones and neonatal weight, height and head circumference in women with impaired glucose tolerance test: randomized clinical controlled trial
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It is well known that normal pregnancy exposes mothers to a diabetogenic state. The important role of adipose tissue in the regulation of insulin resistance has been repeatedly proven. This organ carries out the regulation of insulin resistance by producing adipocytokines involved in the pathogenesis of gestational diabetes mellitus (GDM). The present study aims to evaluate the effects of zinc supplementation on serum leptin, visfatin, tumor necrosis factor-α (TNF-α), adiponectin and zinc-α2-glycoprotein (ZAG) levels in pregnant women with impaired glucose tolerance test (IGTT) results.
In this randomized, placebo-controlled, double-blind clinical trial, 46 pregnant women with impaired glucose tolerance test results were randomly distributed into zinc (n = 23) and placebo (n = 23) groups and received 30 mg zinc supplement per day in the form of zinc gluconate and placebo, respectively, for 8 consecutive weeks. The study was conducted in the Shabestar district of northwestern Iran.
Supplementation after adjusting for confounding variables resulted in a significant reduction in plasma leptin (p = 0.035) and TNF-α (p = 0.027) levels in the zinc group compared with the placebo group. Serum visfatin levels were significantly increased, and serum ZAG levels were significantly decreased in both groups. However, the changes in adiponectin concentration were not significant in either group after intervention nor were the anthropometric parameters in fetuses whose mothers received the zinc supplement.
It seems that zinc supplementation may be considered as a complementary supplement together with the medical management of patients with IGT or GDM. However, further studies are needed before definite conclusions can be drawn.
KeywordsZinc Leptin Visfatin Zinc-–α2-glycoprotein Pregnancy
This work was supported by the Research Vice-chancellor and Nutrition Research Center of Tabriz University of Medical Sciences. The participation of all patients in this study is gratefully acknowledged.
This work was supported by the Tabriz University of Medical Sciences [grant number: 91227].
NR, ATE, NM, and MA performed the research and contributions to design of the study. NR prepared the primary draft. HM, NF, and MAJ: contribution to data analysis; ATE and MA: edited the final draft and final approval of the manuscript.
Compliance with ethical standards
All the participants filled in the informed written consent and the researcher got the ethical permission for the study from the ethics committee of Tabriz University of Medical Sciences. The current study is registered in the Iranian Registry of Clinical Trials (IRCT registration number: IRCT 201212265670 N6) and full trial protocol can be accessed in IRCT website.
Conflict of interest
The authors declare that they have no conflicts of interest.
The study conformed to the 1964 Helsinki declaration and its later amendments. The study was approved by the ethics committee of Tabriz University of Medical Sciences.
Informed consent was obtained from all individual participants included in the study.
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