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Pentraxin 3 and epicardial fat thickness are independently associated with diabetic retinopathy in diabetic patients

  • Elif Turan
  • Kadir Kırboğa
  • Yaşar Turan
  • Ayşe Yeşim Göçmen
Original Article
  • 18 Downloads

Abstract

Previous studies have shown that diabetic retinopathy and inflammation are closely related. Pentraxin 3 (PTX3), high-sensitive C-reactive protein (HsCRP), and epicardial fat thickness (EFT) are parameters associated with inflammation. The aim of this cross-sectional study, was to determine if the levels of HsCRP, PTX3, and EFT were predictors or markers for diabetic retinopathy (DR). Cross-sectional study, 40 normal, nondiabetic subjects (group1), 50 type 2 diabetic patients without DR (group2), and 110 type 2 diabetic patients with DR (group3) were included. PTX3 and HsCRP concentrations were measured and transthoracic echocardiography was used to measure EFT. ANOVA and the post hoc multiple comparisons showed that differences among group 1 and group 2 and also among group 2 and group 3 for PTX3 (p < 0.01 and p = 0.018, respectively), for HsCRP (p < 0.01 and p = 0.042, respectively), and for EFT (p < 0.01 and p = 0.021, respectively) were statistically significant. The difference in serum creatinine was statistically significant only among group 2 and group 3 (p < 0.01). Diabetes duration (OR = 1.116, p < 0.01), PTX3 (OR = 8.516, p = 0.039), EFT (OR = 1.444, p = 0.02), and serum creatinine level (OR = 15.45, p = 0.015) have independent association with DR. Besides, the well-known factors such as diabetes duration and serum creatinine, PTX3, as a marker of inflammation, and EFT, as a marker of inflammation and vascular damage, were independently associated with DR in diabetic patients. Clinical trial number: 20.03.2015/30

Keywords

Diabetic retinopathy Pentraxin 3 HsCRP Epicardial fat tissue 

Notes

Funding

This study was funded by the Scientific Research Projects of the University of Bozok.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Bozok University Clinical Research Ethics Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Research Society for Study of Diabetes in India 2018

Authors and Affiliations

  1. 1.School of Medicine, Division of Endocrinology and MetabolismBozok UniversityYozgatTurkey
  2. 2.School of Medicine, Division of OphthalmologyBozok UniversityYozgatTurkey
  3. 3.School of Medicine, Division of CardiologyBozok UniversityYozgatTurkey
  4. 4.School of Medicine, Division BiochemistryBozok UniversityYozgatTurkey

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