Left atrial diameter is associated with target organ damage in patients with type 2 diabetes mellitus

  • Wei He
  • Wenhui Zhu
  • Yanqiu Liu
  • Min Ye
  • Haoyu Wang
  • Wei Li
  • Hong Lin
  • Donghong Liu
  • Fengjuan YaoEmail author
Original Article


This paper aims to investigate whether there is a relationship between left atrial diameter (LAD) and target organ damage (TOD) in patients with type 2 diabetes mellitus (DM). Two-hundred-and-eleven patients with type 2 DM were recruited. Data on left ventricular mass index (LVMI), diabetic retinopathy, carotid intima–media thickness/carotid plaque, micro-albuminuria, and serum creatinine levels were collected to determine whether TOD occurred in patients with type 2 DM. Age, body mass index, waist-hip ratio, a history of DM, Framingham Score, and 10-year risk were used to assess cardiovascular disease risk. Patients were divided into four groups: zero TOD (group I, n = 50), one TOD marker (group II, n = 76), two TOD markers (group III, n = 51), and at least three TOD markers (group IV, n = 34). Using multivariate regression analyses, age, body mass index, waist-hip ratio, a history of DM, Framingham Score, and 10-year risk were significantly associated with LAD. LAD was associated with an increased number of markers for TOD. Univariate analyses demonstrated significant relationships between LAD and TOD in the context of serum creatinine and urinary albumin creatinine ratio (r = 0.292, p < 0.001), creatinine (r = 0.346, p < 0.001), carotid intima–media thickness (r = 0.128, p = 0.032), and LVMI (r = 0.399, p < 0.001). Multivariate regression analyses also determined that LVMI and creatinine were independent predictors of LAD enlargement. LAD may be associated with cardiovascular disease risk. LAD enlargement could be an effective indicator of TOD, particularly renal impairment and left ventricular hypertrophy. Screening for LAD may offer a new and rapid approach for evaluating the severity of DM.


Diabetes mellitus Left atrial Cardiomyopathy left ventricular mass Echocardiography 


Authors’ contributions

Concept/design: Wei He, Wenhui Zhu, Fengjuan Yao.

Data collection/data analysis/interpretation: Wei He, Wenhui Zhu, Yanqiu Liu, Min Ye.

Drafting article: Wei He, Wenhui Zhu, Wei Li, Hong Lin, Donghong Liu.

Critical revision of article: Haoyu Wang, BSc, Fengjuan Yao.

Running title: Left atrial diameter and target organ damage.

Approval of article: Wei He, Wenhui Zhu,Yanqiu Liu, Min Ye, Haoyu Wang, BSc, Wei Li, Hong Lin, Donghong Liu, Fengjuan Yao.


This work was supported by a grant from the Guangdong Province Science Foundation (No. 20140212; Guangzhou, China).

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Research Society for Study of Diabetes in India 2018

Authors and Affiliations

  • Wei He
    • 1
  • Wenhui Zhu
    • 2
    • 3
  • Yanqiu Liu
    • 1
  • Min Ye
    • 1
  • Haoyu Wang
    • 4
  • Wei Li
    • 1
  • Hong Lin
    • 1
  • Donghong Liu
    • 1
  • Fengjuan Yao
    • 1
    Email author
  1. 1.Department of UltrasoundThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina
  2. 2.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic CentreSun Yat-sen UniversityGuangzhouChina
  3. 3.Department of OphthalmologyThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina
  4. 4.School of MedicineUniversity of ManchesterManchesterUK

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