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Development of a novel thermo-responsive hydrogel-coated gold nanorods as a drug delivery system

  • Mehran Kurdtabar
  • Gazal Baghestani
  • Ghasem Rezanejade Bardajee
Original Paper

Abstract

In this study, at first, gold nanorods (GNRs) were synthesized and then they were coated with a layer of hydrogel composed of poly(N-isopropylacrylamide) (PNIPAM) grafted onto carboxymethyl cellulose (CMC) as a backbone. The chemical structure of GNRs/PNIPAM-g-CMC hydrogel was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), atomic-force microscopy (AFM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The swelling properties of the obtained GNRs/PNIPAM-g-CMC hydrogel were studied at different times and temperatures. In addition, drug release from doxorubicin-loaded GNRs/PNIPAM-g-CMC hydrogel was examined at different temperatures during time. The drug release mechanism was studied by first-order, second-order, and Ritger–Peppas models. Finally, the GNRs/PNIPAM-g-CMC hydrogel biocompatibility was tested against L929 mouse fibroblast cells by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method. Our study suggests that GNRs coated with low-cost hydrogels can be excellent candidate for drug delivery systems.

Keywords

Gold nanorod Drug delivery Hydrogel Carboxymethyl cellulose N-isopropyl acrylamide 

Notes

Funding information

This work was funded by the Karaj Islamic Azad University, PNU, and INSF.

References

  1. 1.
    Soroory H, Mashak A, Rahimi A (2013) Application of PDMS-based coating in drug delivery systems using PVP as channeling agent. Iran Polym J 22:791–797CrossRefGoogle Scholar
  2. 2.
    Rafienia M, Zarinmehr B, Poursamar S A, Bonakdar S, Ghavami M, Janmaleki M (2013) Coated urinary catheter by PEG/PVA/gentamicin with drug delivery capability against hospital infection. Iran Polym J 22:75–83CrossRefGoogle Scholar
  3. 3.
    Saikia C, Hussain A, Ramteke A, Sharma HK, Deb P, Maji TK (2015) Carboxymethyl starch-coated iron oxide magnetic nanoparticles: a potential drug delivery system for isoniazid. Iran Polym J 24:815–828CrossRefGoogle Scholar
  4. 4.
    Abasian M, Hooshangi V, Moghadam PN (2017) Synthesis of polyvinyl alcohol hydrogel grafted by modified Fe3O4 nanoparticles: characterization and doxorubicin delivery studies. Iran Polym J 26:313–322CrossRefGoogle Scholar
  5. 5.
    Hassanzadeh F, Maaleki S, Varshosaz J, Khodarahmi GA, Farzan M, Rostami M (2016) Thermosensitive folic acid-targeted poly (ethylene-co-vinyl alcohol) hemisuccinate polymeric nanoparticles for delivery of epirubicin to breast cancer cells. Iran Polym J 25:967–976CrossRefGoogle Scholar
  6. 6.
    Haine AT, Koga Y, Hashimoto Y, Higashi T, Niidome T (2017) Enhancement of transdermal protein delivery by photothermal effect of gold nanorods coated on polysaccharide-based hydrogel. Eur J Pharm Biopharm 119:91–95CrossRefGoogle Scholar
  7. 7.
    Parida S, Maiti C, Rajesh Y, Dey KK, Mandal M (2017) Gold nanorod embedded reduction responsive block copolymer micelle-triggered drug deliverycombined with photothermal ablation for targeted cancer therapy. Biochim Biophys Acta Gen Subj 1861:3039–3052CrossRefGoogle Scholar
  8. 8.
    Zhang P, Li B, Du J, Wang Y (2017) Regulation the morphology of cationized gold nanoparticles for effective gene delivery. Colloids Surf B: Biointerfaces 157:18–25CrossRefGoogle Scholar
  9. 9.
    Zhang W, Wang F, Wang Y, Wang J, Zhou D (2016) pH and near-infrared light dual-stimuli responsive drug delivery using DNA-conjugated goldnanorods for effective treatment of multidrug resistant cancer cells. J Control Release 232:9–19CrossRefGoogle Scholar
  10. 10.
    Yan E, Cao M, Wang Y, Hao X, Zhang D (2016) Gold nanorods contained polyvinyl alcohol/chitosan nanofiber matrix for cell imaging and drugdelivery. Mater Sci Eng C 58:1090–1097CrossRefGoogle Scholar
  11. 11.
    Sau TK, Murphy CJ (2004) Seeded high yield synthesis of short au nanorods in aqueous solution. Langmuir 20:6414–6420CrossRefGoogle Scholar
  12. 12.
    Orendorff CJ, Hankins PL, Murphy CJ (2005) pH-triggered assembly of gold nanorods. Langmuir 21:2022–2026CrossRefGoogle Scholar
  13. 13.
    Garabagiu S, Bratu I (2013) Thiol containing carboxylic acids remove the CTAB surfactant onto the surface of gold nanorods: an FTIR spectroscopic study. Appl Surf Sci 284:780–783CrossRefGoogle Scholar
  14. 14.
    Casas J, Venkataramasubramani M, Wang Y (2013) Liang tang, replacement of cetyltrimethylammoniumbromide bilayer on gold nanorod by alkanethiolcrosslinker for enhanced plasmon resonance sensitivity. Biosens Bioelectron 49:525–530CrossRefGoogle Scholar
  15. 15.
    Du YK, Xu JZ, Shen M, Yang P, Jiang L (2005) Alkanethiol-stabilized decahedron of gold nanoparticles. Colloids Surf A Physicochem Eng Asp 257-258:535–537CrossRefGoogle Scholar
  16. 16.
    Bogliotti N, Oberleitner B, Di-Cicco A, Schmidt F, Semetey V (2001) Optimizing the formation of biocompatible gold nanorods for cancer research: functionalization, stabilization and purification. J Colloid Interface Sci 357:75–81CrossRefGoogle Scholar
  17. 17.
    Mlambo M, Mdluli PS, Shumbula P, Mpelane S, Tshikhudo R (2013) Synthesis and characterization of mixed monolayer protected gold nanorods and their Raman activities. Mater Res Bull 48:4181–4185CrossRefGoogle Scholar
  18. 18.
    Hu J, Hua Q, Deng W, Wang Y (2017) Fabrication of P(NIPAM-AM)@au NRs hollow spheres for near-infrared controlled photothermal drug release. J Control Release 259:e65–e66CrossRefGoogle Scholar
  19. 19.
    Karg M, Hellweg T (2009) New “smart” poly(NIPAM) microgels and nanoparticle microgel hybrids: properties and advances in characterisation. Curr Opin Colloid 14:438–450CrossRefGoogle Scholar
  20. 20.
    Niidome T, Shiotani A, Mori T, Katayama Y (2010) Targeted delivery of gold nanorods modified with thermo-sensitive polymer. J Control Release 148:e65–e66CrossRefGoogle Scholar
  21. 21.
    Farooqi ZH, Khan HU, Shah SM, Siddiq M (2017) Stability of poly(N-isopropylacrylamide-co-acrylic acid) polymer microgels under various conditions of temperature, pH and salt concentration. Arab J Chem 10:329–335CrossRefGoogle Scholar
  22. 22.
    Begum R, Farooqi ZH, Khan SR (2016) Poly (N-isopropylacrylamide-acrylic acid) copolymer microgels for various applications: a review. Int J Polym Mater Poly 65:841–852CrossRefGoogle Scholar
  23. 23.
    Farooqi ZH, Siddiq M (2015) Temperature responsive poly(N- isopropylacrylamide-acrylamide-phenylboronic acid) microgels for stabilization of silver nanoparticles. J Dispers Sci Technol 36:423–429CrossRefGoogle Scholar
  24. 24.
    Farooqi ZH, Butt Z, Begum R, Khan SR, Sharif A, Ahmed E (2015) Poly(N-isopropylacrylamide-co-methacrylic acid) microgel stabilized copper nanoparticles for catalytic reduction of nitrobenzene. Mater Sci-Poland 33:627–634CrossRefGoogle Scholar
  25. 25.
    Naeem H, Farooqi ZH, Shah LA, Siddiq M (2012) Synthesis and characterization of p(NIPAM-AA-AAm) microgels for tuning of optical properties of silver nanoparticles. J Polym Res 19:9950–9960CrossRefGoogle Scholar
  26. 26.
    Begum R, Farooqi ZH, Ahmed E, Naseem K, Ashraf S, Sharif A, Rehan R (2017) Catalytic reduction of 4-nitrophenol using silver nanoparticles-engineered poly(N-isopropylacrylamide-co-acrylamide) hybrid microgels. Appl Organomet Chem 31:e3563CrossRefGoogle Scholar
  27. 27.
    Hu J, Zheng S, Xu X (2012) Dual stimuli responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels based on a β-cyclodextrin crosslinker: synthesis, properties, and controlled protein release. J Polym Res 19:9988CrossRefGoogle Scholar
  28. 28.
    Navaei A, Saini H, Christenson W, Sullivan RT, Nikkhah M (2016) Gold nanorod-incorporated gelatin-based conductive hydrogels for engineering cardiac tissue constructs. Acta Biomater 41:133–146CrossRefGoogle Scholar
  29. 29.
    Gorelikov I, Field LM, Kumacheva E (2004) Hybrid microgels photoresponsive in the near-infrared spectral range. J Am Chem Soc 126:15938–15939CrossRefGoogle Scholar
  30. 30.
    Farooqi ZH, Khan SR, Begum R, Ijaz A (2016) Review on synthesis, properties, characterization and applications of gold nanostructures fabricated responsive microgels. Rev Chem Eng 32:49–69CrossRefGoogle Scholar
  31. 31.
    Pourjavadi A, Tehrani ZM, Salimi H, Banazadeh A, Abedini N (2015) Hydrogel nanocomposite based on chitosan-g-acrylic acid and modified nanosilica with high adsorption capacity for heavy metal ion removal. Iran Polym J 24:725–734CrossRefGoogle Scholar
  32. 32.
    Xiang Y, Xu W, Ou E, Su Q, LChen ZY, Xia X, Xiong Y, Xiong Y (2013) Preparation and characterization of strongly swellable modified-lignosulfonate hydrogel particles. Iran Polym J 22:749–756CrossRefGoogle Scholar
  33. 33.
    Zhou M, Ye X, Liu K, Hu J, Qian X (2015) Tunable thermo-responsive supramolecular hydrogel: design, characterization, and drug release. J Polym Res 22:170CrossRefGoogle Scholar
  34. 34.
    Bardajee GR, Hooshyar Z (2017) Drug release study by a novel thermo sensitive nanogel based on salep modified graphene oxide. J Polym Res 24:49CrossRefGoogle Scholar
  35. 35.
    Chen YM, Sun L, Yang SA, Shi L, Hu C (2017) Self-healing and photoluminescent carboxymethyl cellulose-based hydrogels. Eur Polym J 94:501–510CrossRefGoogle Scholar
  36. 36.
    Barkhordari S, Yadollahi M, Namazi H (2014) pH sensitive nanocomposite hydrogel beads based on carboxymethyl cellulose/layered double hydroxide as drug delivery systems. J Polym Res 21:454CrossRefGoogle Scholar
  37. 37.
    Ma M, Tan L, Dai Y, Zhou J (2013) An investigation of flavor encapsulation comprising of regenerated cellulose as core and carboxymethyl cellulose as wall. Iran Polym J 22:689–695CrossRefGoogle Scholar
  38. 38.
    Hashmi ASK, Hutchings GJ (2006) Gold catalysis. Angew Chem Int Ed 45:7896–7936CrossRefGoogle Scholar
  39. 39.
    Farooqi ZH, Ijaz A, Begum R, Naseem K, Usman M, Ajmal M, Saeed U (2016) Synthesis and characterization of inorganic–organic polymer microgels for catalytic reduction of 4-Nitroaniline in aqueous medium. Polym Compos 39:645–653.  https://doi.org/10.1002/pc.23980 CrossRefGoogle Scholar
  40. 40.
    Farooqi ZH, Naseem K, Begum R, Ijaz A (2015) Catalytic reduction of 2-Nitroaniline in aqueous medium using silver nanoparticles functionalized polymer microgels. J Inorg Organomet Polym Mater 25:1554–1568CrossRefGoogle Scholar
  41. 41.
    Khutale GV, Casey A (2017) Synthesis and characterization of a multifunctional gold-doxorubicin nanoparticle system for pH triggered intracellular anticancer drug release. Eur J Pharm Biopharm 119:372–380CrossRefGoogle Scholar
  42. 42.
    Yamashita s FH, Akiyama Y, Niidome Y, Niidome T (2011) Controlled-release system of single-stranded DNA triggered by the photothermal effect of goldnanorods and its in vivo application. Bioorg Med Chem 19:2130–2135CrossRefGoogle Scholar
  43. 43.
    Dash S, Murthy PN, Nath L, Chowdhury P (2010) Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 67:217–223Google Scholar
  44. 44.
    Wang Y, Wang J, Yuan Z, Han H, Guo X (2017) Chitosan cross-linked poly(acrylic acid) hydrogels: drug release control and mechanism. Colloids Surf B: Biointerfaces 152:252–259CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceIslamic Azad University, Karaj BranchKarajIran
  2. 2.Department of ChemistryPayame Noor UniversityTehranIran

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