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HMGB1: an overview of its versatile roles in the pathogenesis of colorectal cancer

  • Kim Jun Cheng
  • Mohammed Abdullah Alshawsh
  • Elsa Haniffah Mejia Mohamed
  • Surendran Thavagnanam
  • Ajantha Sinniah
  • Zaridatul Aini IbrahimEmail author
Review
  • 60 Downloads

Abstract

Background

In recent years, the high mobility group box-1 (HMGB1) protein, a damage-associated molecular pattern (DAMP) molecule, has been found to play multifunctional roles in the pathogenesis of colorectal cancer. Although much attention has been given to the diagnostic and prognostic values of HMGB1 in colorectal cancer, the exact functional roles of the protein as well as the mechanistic pathways involved have remained poorly defined. This systematic review aims to discuss what is currently known about the roles of HMGB1 in colorectal cancer development, growth and progression, and to highlight critical areas for future investigations. To achieve this, the bibliographic databases Pubmed, Scopus, Web of Science and ScienceDirect were systematically screened for articles from inception till June 2018, which address associations of HMGB1 with colorectal cancer.

Conclusions

HMGB1 plays multiple roles in promoting the pathogenesis of colorectal cancer, despite a few contradicting studies. HMGB1 may differentially regulate disease-related processes, depending on the redox status of the protein in colorectal cancer. Binding of HMGB1 to various protein partners may alter the impact of HMGB1 on disease progression. As HMGB1 is heavily implicated in the pathogenesis of colorectal cancer, it is crucial to further improve our understanding of the functional roles of HMGB1 not only in colorectal cancer, but ultimately in all types of cancers.

Keywords

Colorectal cancer High mobility group box 1 DAMP 

Notes

Acknowledgements

All authors would like to thank Thanusha Ganesan for her kind assistance and contributions.

Funding information

This research was supported by the University of Malaya Research Fund Assistance (BKP) (Grant no. BK021–2018).

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Supplementary material

13402_2019_477_MOESM1_ESM.docx (68 kb)
ESM 1 (DOCX 67 kb)
13402_2019_477_MOESM2_ESM.pptx (64 kb)
ESM 2 Supplementary Fig. 1. Overall Kaplan-Meier survival estimates (adapted from http://bit.ly/2yuszxf [104, 105]). Cases without genetic alterations in HMGB1, shown in blue (n = 509), exhibit lower overall survival rates compared to cases without, shown in red (n = 13). (PPTX 63 kb)
13402_2019_477_MOESM3_ESM.pptx (63 kb)
ESM 3 Supplementary Fig. 2. Disease/progression-free Kaplan-Meier estimates (adapted from http://bit.ly/2yuszxf [104, 105]). Cases without genetic alterations in HMGB1, shown in blue (n = 188), exhibit higher relapse rates compared to cases without, shown in red (n = 9). (PPTX 63 kb)

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Copyright information

© International Society for Cellular Oncology 2019

Authors and Affiliations

  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia
  2. 2.Paediatric DepartmentRoyal London HospitalLondonUK

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