Cellular Oncology

, Volume 42, Issue 2, pp 131–141 | Cite as

MicroRNA-mediated redox regulation modulates therapy resistance in cancer cells: clinical perspectives

  • Safieh Ebrahimi
  • Seyed Isaac HashemyEmail author



Chemotherapy and radiation therapy are the most common types of cancer therapy. The development of chemo/radio-resistance remains, however, a major obstacle. Altered redox balances are among of the main factors mediating therapy resistance. Therefore, redox regulatory strategies are urgently needed to overcome this problem. Recently, microRNAs have been found to act as major redox regulatory factors affecting chemo/radio-resistance. MicroRNAs play critical roles in regulating therapeutic resistance through the regulation of antioxidant enzymes, redox-sensitive signaling pathways, cancer stem cells, DNA repair mechanisms and autophagy.


Here, we summarize current knowledge on microRNA-mediated redox regulatory mechanisms underlying chemo/radio-resistance. This knowledge may form a basis for a better clinical management of cancer patients.


Cancer Chemotherapy Radiotherapy Resistance MicroRNA Redox regulation 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© International Society for Cellular Oncology 2019

Authors and Affiliations

  1. 1.Department of Clinical Biochemistry, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  2. 2.Student Research CommitteeMashhad University of Medical SciencesMashhadIran
  3. 3.Surgical Oncology Research CenterMashhad University of Medical SciencesMashhadIran

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