Journal of NeuroVirology

, Volume 25, Issue 5, pp 619–621 | Cite as

Guest Editorial: Perspectives on HIV and other age-related neurological diseases

  • T. Dianne LangfordEmail author
  • Jennifer Gordon


Over half of people with HIV (PWH) in the United States are 50 years of age or older (Prevention, C.f.D.C.a 2018). Among new infections, 17% of PWH were over the age of 50 years in the US in 2016. In fact, today PWH on combination anti-retroviral therapy (cART) rarely die from complications of AIDS, but instead suffer from age-related complications including neurocognitive decline and neurodegeneration of underlying HIV-associated neurocognitive disorders (HAND). Despite the success of cART, the prevalence of HAND is not decreasing and appears to be more severe in aging PWH. This special issue features articles that highlight parallels or differences in HIV-associated neurodegeneration/neurocognitive impairments with other age-related CNS disorders. Among the featured articles, authors address overlap between Alzheimer’s disease (AD) and HAND and neurodegeneration and the challenges faced in the search for biomarkers specific for HIV-associated CNS dysfunction. The life...





  1. Gelman BB (2015) Neuropathology of HAND with suppressive antiretroviral therapy: encephalitis and neurodegeneration reconsidered. Curr HIV/AIDS Rep 12:272–279CrossRefGoogle Scholar
  2. Gelman BB et al (2012) The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment. PLoS One 7:e46178CrossRefGoogle Scholar
  3. Hategan A et al (2017) HIV Tat protein and amyloid-beta peptide form multifibrillar structures that cause neurotoxicity. Nat Struct Mol Biol 24:379–386CrossRefGoogle Scholar
  4. Natarajaseenivasan K et al (2018) Astrocytic metabolic switch is a novel etiology for cocaine and HIV-1 Tat-mediated neurotoxicity. Cell Death Dis 9:415CrossRefGoogle Scholar
  5. Prevention, C.f.D.C.a., Vol. 2019. (ed. D.o.H.A. Prevention) (CDC, Online; 2018)Google Scholar

Copyright information

© Journal of NeuroVirology, Inc. 2019

Authors and Affiliations

  1. 1.Department of Neuroscience and Center for NeurovirologyLewis Katz School of Medicine at Temple UniversityPhiladelphiaUSA

Personalised recommendations