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Hypertrophic chronic pachymeningitis associated with Epstein-Barr virus reactivation: a case report

  • Raffaele NardoneEmail author
  • Francesco Brigo
  • Markus Covi
  • Luca Carnicelli
  • Francesca Caleri
  • Hannes Tischler
  • Larissa Hauer
  • Johann Sellner
Case Report

Abstract

Hypertrophic pachymeningitis is a rare inflammatory condition characterized by the thickening of the dura mater. We describe a patient who presented with intractable headache and complex cranial nerve palsy. Hypertrophy of the frontal dura was accompanied by pleocytosis and detection of Epstein-Barr virus (EBV) by PCR in cerebrospinal fluid. Clinical symptoms gradually improved after acyclovir and corticosteroid treatment, whereas dural pathology remained unchanged on neuroimaging. This case points at an expansion of the spectrum of neurological manifestations for EBV.

Keywords

Hypertrophic pachymeningitis Epstein-Barr virus Neuroinflammation Acyclovir Corticosteroid treatment 

Notes

References

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Copyright information

© Journal of NeuroVirology, Inc. 2019

Authors and Affiliations

  • Raffaele Nardone
    • 1
    • 2
    Email author
  • Francesco Brigo
    • 1
  • Markus Covi
    • 1
  • Luca Carnicelli
    • 1
  • Francesca Caleri
    • 1
  • Hannes Tischler
    • 1
  • Larissa Hauer
    • 3
  • Johann Sellner
    • 2
    • 4
  1. 1.Department of NeurologyFranz Tappeiner HospitalMerano (BZ)Italy
  2. 2.Department of NeurologyChristian Doppler Medical CenterSalzburgAustria
  3. 3.Department of Psychiatry, Psychotherapy and Psychosomatic MedicineChristian Doppler Medical CenterSalzburgAustria
  4. 4.Department of Neurology, Klinikum rechts der IsarTechnische Universität MünchenMunichGermany

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