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MRI reveals segmental distribution of enterovirus lesions in the central nervous system: a probable clinical evidence of retrograde axonal transport of EV-A71

  • Hehong LiEmail author
  • Ling Su
  • Tao Zhang
  • Fan He
  • Yingxian YinEmail author
Article
  • 5 Downloads

Abstract

Enterovirus 71 (EV-A71) is a major causative agent for hand, foot, and mouth disease (HFMD), especially severe HFMD characterized by neurologic involvement. The objective of this study is to investigate the relationship between the distribution of neurologic infection and the outcomes of severe HFMD. A total of 139 suspected severe HFMD cases (92 were confirmed as EV-A71 infection) underwent clinical and laboratory diagnosis as well as magnetic resonance imaging (MRI) scans of the nervous system. Only those who were confirmed with EV-A71 infection were included in our study. The image data of severe EV-A71-related HFMD cases were retrospectively analyzed, and they were grouped according to lesion site location indicated by MRI. The distribution of lesions in the central nervous system shown by MRI indicated that there were 47 (51%) in brainstem, 33 (36%) in spinal nerve roots lower than T1 thoracic spine, four (5%) in brainstem plus cervical spinal cord involvement, three (3%) in cervical spinal cord, three (3%) in brainstem plus spinal nerve root lower than T1, and two (2%) in cervical and thoracic spinal cord lower than T1. Our analysis strongly substantiates the hypothesis of retrograde axonal transport (RAT) of EV-A71 pathogenesis, suggesting that the pharyngeal branch of the vagus nerve is a major route to the brainstem, and that ascending transportation via the spinal cord does not occur when spinal nerve roots are infected by EV-A71 via RAT.

Graphical abstract

Keywords

Enterovirus 71 (EV-A71) Hand, foot and mouth disease (HFMD) Infection Magnetic resonance imaging (MRI) Retrograde axonal transport (RAT) 

Notes

Acknowledgments

We thank Ann Turnley, PhD, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text draft of this manuscript.

Author contribution

HL designed and supervised the study. LS collected and analyzed data. TZ and FH collected and collated data. YY designed study and write the manuscript.

Funding information

This work was supported by the Science and Technology Planning Project of Guangdong Province, China (2017A020215071).

Supplementary material

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Copyright information

© Journal of NeuroVirology, Inc. 2019

Authors and Affiliations

  1. 1.Department of Radiology, Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina
  2. 2.Department of Genetics and Endocrinology, Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina
  3. 3.Guangzou Institute of Pediatrics, Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina

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