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High-dose corticosteroids for acute cytomegalovirus-associated transverse myelitis in the immunocompetent patient: a case report and systematic review

  • A. BudhramEmail author
  • Y. Liu
  • M. Krawczyk
  • T. L. H. Chan
  • J. G. Burneo
  • S. M. Hosseini-Moghaddam
  • C. Shoesmith
Short Communication

Abstract

We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use of immunosuppressive therapy for this potentially infectious myelopathy, we systematically reviewed the literature to assess outcomes after administration of high-dose corticosteroids to this population. Despite severe disease at clinical nadir with inability to ambulate, immunocompetent patients with acute CMV-associated TM who received high-dose corticosteroids had good clinical outcomes 1 month to 1 year after presentation.

Keywords

Cytomegalovirus Myelitis Methylprednisolone Corticosteroids Immunocompetent 

Notes

Compliance with ethical standards

Conflicts of interest

The authors declare they have no conflicts of interest.

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Copyright information

© Journal of NeuroVirology, Inc. 2019

Authors and Affiliations

  • A. Budhram
    • 1
    Email author
  • Y. Liu
    • 2
  • M. Krawczyk
    • 1
  • T. L. H. Chan
    • 1
  • J. G. Burneo
    • 1
  • S. M. Hosseini-Moghaddam
    • 3
  • C. Shoesmith
    • 1
  1. 1.Department of Clinical Neurological Sciences, Division of Neurology, University HospitalWestern UniversityLondonCanada
  2. 2.Department of Medicine, Division of General Internal MedicineWestern UniversityLondonCanada
  3. 3.Department of Medicine, Division of Infectious DiseasesWestern UniversityLondonCanada

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