Zika virus outbreak in New Caledonia and Guillain-Barré syndrome: a case-control study

  • Olivier Simon
  • Blandine Acket
  • Carole Forfait
  • Dominique Girault
  • Ann-Claire Gourinat
  • Pauline Millon
  • Maguy Daures
  • Jessica Vanhomwegen
  • Segolene Billot
  • Antoine Biron
  • Damien Hoinard
  • Elodie Descloux
  • David Guyon
  • Jean Claude Manuguerra
  • Sylvie Laumond
  • Nicolas Molko
  • Myrielle Dupont-Rouzeyrol
Short Communication

Abstract

Zika virus (ZIKV) infection has been associated with neurologic disorders including Guillain-Barré syndrome (GBS). In New Caledonia during the ZIKV outbreak (2014–2015), case-control and retrospective studies have been performed to assess the link between ZIKV and GBS. Among the 15 cases included, 33% had evidence of a recent ZIKV infection compared to only 3.3% in the 30 controls involved. All patients were Melanesian, had facial diplegia and similar neurophysiological pattern consistent with acute inflammatory demyelinating polyneuropathy, and recovered well. Furthermore, during the peak of ZIKV transmission, we observed a number of GBS cases higher than the calculated upper limit, emphasizing the fact that ZIKV is now a major trigger of GBS.

Keywords

Guillain-Barré syndrome Case control study Zika virus New Caledonia 

Notes

Acknowledgments

We thank Julie Sevila and Jean-Paul Grangeon (New Caledonia Health Department, Noumea) and Magali Teurlai (Institut Pasteur in New Caledonia, Noumea) for fruitful discussion in setting up the protocol. We thank Cyrille Goarant (Institut Pasteur in New Caledonia, Noumea) for revising the manuscript. We thank Vincent Richard (Institut Pasteur in New Caledonia, Noumea) for statistical analysis.

Compliance with ethical standards

Conflict of interests

The authors declare that they have no conflict of interest.

Supplementary material

13365_2018_621_MOESM1_ESM.xlsx (14 kb)
ESM 1 (XLSX 13 kb)

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Copyright information

© Journal of NeuroVirology, Inc. 2018

Authors and Affiliations

  • Olivier Simon
    • 1
  • Blandine Acket
    • 2
  • Carole Forfait
    • 3
  • Dominique Girault
    • 4
  • Ann-Claire Gourinat
    • 5
  • Pauline Millon
    • 1
  • Maguy Daures
    • 3
  • Jessica Vanhomwegen
    • 6
  • Segolene Billot
    • 1
  • Antoine Biron
    • 5
  • Damien Hoinard
    • 6
  • Elodie Descloux
    • 7
  • David Guyon
    • 1
  • Jean Claude Manuguerra
    • 6
  • Sylvie Laumond
    • 3
  • Nicolas Molko
    • 1
  • Myrielle Dupont-Rouzeyrol
    • 4
  1. 1.Department of NeurologyGaston Bourret Territorial HospitalNoumeaNew Caledonia
  2. 2.Department of NeurophysiologyCentre Hospitalier UniversitaireToulouseFrance
  3. 3.New Caledonia Health DepartmentNoumeaNew Caledonia
  4. 4.Dengue and Arboviruses Expertise and Research Unit, Institut Pasteur International NetworkInstitut Pasteur in New CaledoniaNouméaNew Caledonia
  5. 5.Immuno-Serology and Molecular Biology Laboratory, Institut Pasteur International NetworkInstitut Pasteur in New CaledoniaNoumeaNew Caledonia
  6. 6.Environment and Infectious Risks UnitInstitut PasteurParisFrance
  7. 7.Department of Infectious DiseasesGaston Bourret Territorial HospitalNoumeaNew Caledonia

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