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Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

  • Deanna SaylorEmail author
  • Gertrude Nakigozi
  • Carlos A. Pardo
  • Alice Kisakye
  • Anupama Kumar
  • Noeline Nakasujja
  • Kevin R. Robertson
  • Ronald H. Gray
  • Maria J. Wawer
  • Ned Sacktor
Short Communication
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Abstract

We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

Keywords

HIV-associated neurocognitive disorder Vitamin D HIV Africa Epidemiology 

Notes

Acknowledgements

The authors would like to thank the study participants and staff at the Rakai Health Sciences Program for the time and effort they dedicated to this study.

Sources of support

This study is supported by the National Institutes of Health (MH099733, MH075673, MH080661-08, L30NS088658, NS065729-05S2, P30AI094189-01A1) and the Johns Hopkins Center for Global Health.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Journal of NeuroVirology, Inc. 2019

Authors and Affiliations

  • Deanna Saylor
    • 1
    • 2
    Email author
  • Gertrude Nakigozi
    • 3
  • Carlos A. Pardo
    • 1
  • Alice Kisakye
    • 3
  • Anupama Kumar
    • 1
  • Noeline Nakasujja
    • 4
  • Kevin R. Robertson
    • 5
  • Ronald H. Gray
    • 6
  • Maria J. Wawer
    • 6
  • Ned Sacktor
    • 1
  1. 1.Department of NeurologyJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of MedicineUniversity of Zambia School of MedicineLusakaZambia
  3. 3.Rakai Health Sciences ProgramKalisizoUganda
  4. 4.Department of PsychiatryMakerere UniversityKampalaUganda
  5. 5.Department of NeurologyUniversity of North Carolina-Chapel HillChapel HillUSA
  6. 6.Department of EpidemiologyJohns Hopkins University Bloomberg School of Public HealthBaltimoreUSA

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