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Comments on: “Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk”

  • Morteza GholamiEmail author
  • Mahsa M. Amoli
Letter to the Editor

Dear Editor,

Laczmanska (Laczmanska and Sasiadek 2019) recently published a meta-analysis about the association of two polymorphisms in PTPRJ gene (Arg326Gln (rs1503185) and Gln276Pro (rs1566734)) and different types of cancers. They concluded that “the polymorphisms Arg326Gln and Gln276Pro of the PTPRJ gene are not associated with an increased risk of cancer except for the Arg326Gln polymorphism in colorectal cancer”. Their study showed non-significant results for Arg326Gln 1.18(0.94–1.47) and Gln276Pro 1.04(0.96–1.12) in cancer overally and in different subgroup based on the type of cancers. However, there are some misinterpretations in the meta-analysis which should be noticed. Here we aim to comment on the issue and the correct results.

Before everything, unfortunately, there are some errors in text and tables. In their article, the genotyping data in Table 2 for Iuliano (Iuliano et al. 2004), and Mita (Mita et al. 2010) studies are not correct; we present the correct data here in...

Notes

References

  1. Iuliano R, Le PI, Cristofaro C et al (2004) The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis. Oncogene 23:8432–8438.  https://doi.org/10.1038/sj.onc.1207766 CrossRefGoogle Scholar
  2. Iuliano R, Palmieri D, He H et al (2010) Role of PTPRJ genotype in papillary thyroid carcinoma risk. Endocr Relat Cancer.  https://doi.org/10.1677/ERC-10-0143
  3. Laczmanska I, Sasiadek MM (2019) Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk. J Appl Genet 60(1):57–62.  https://doi.org/10.1007/s13353-019-00481-3 CrossRefGoogle Scholar
  4. Mita Y, Yasuda Y, Sakai A et al (2010) Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers. J Cancer Res Clin Oncol.  https://doi.org/10.1007/s00432-009-0656-7
  5. Toland AE, Rozek LS, Presswala S et al (2008) PTPRJ haplotypes and colorectal cancer risk. Cancer Epidemiol Biomark Prev.  https://doi.org/10.1158/1055-9965.EPI-08-0513
  6. van Puijenbroek M, Dierssen JWF, Stanssens P et al (2005) Mass spectrometry-based loss of heterozygosity analysis of single-nucleotide polymorphism loci in paraffin embedded tumors using the MassEXTEND assay: single-nucleotide polymorphism loss of heterozygosity analysis of the protein tyrosine phosphatase receptor type J in familial colorectal cancer. J Mol Diagn 7(5):623–630.  https://doi.org/10.1016/S1525-1578(10)60596-X CrossRefGoogle Scholar
  7. Wei W, Jiang M, Luo L et al (2013) Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population. funpecrp.com.br. Genet Mol Res Genet Mol Res 12:6268–6274.  https://doi.org/10.4238/2013 CrossRefGoogle Scholar

Copyright information

© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2019

Authors and Affiliations

  1. 1.Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  2. 2.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  3. 3.Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran

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