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Novel bergamot oil nanospanlastics combined with PUVB therapy as a clinically translatable approach for vitiligo treatment

  • Mai Shaaban
  • Maha NasrEmail author
  • Abeer Attia Tawfik
  • Maha Fadel
  • Omaima Sammour
Original Article

Abstract

The impact of nanomedicine has grown in the current decade; however, only very few clinical translational attempts have been realized. Therefore in the present study, we hypothesized that bergamot oil, a psoralen-containing oil, would produce an optimized melanogenic effect in the clinical treatment of vitiligo when loaded within an elastic nanocarrier (spanlastics) and combined with PUVB for activation of psoralens. Spanlastics were prepared and characterized for particle size, physical stability, in vitro release, thermal behavior, deformability, morphology, and in vitro photostability. The efficacy of the selected formula was tested histopathologically on rat skin and clinically translated in patients suffering from vitiligo. Results revealed that the spanlastics were of reasonable nanosize, deformable, and provided sustained release of bergamot oil. The incorporation of bergamot oil within spanlastics improved its photostability and its photodynamic activity. Spanlastics exhibited promising clinical results in terms of extent and onset of repigmentation in vitiligo patients. Therefore, it can be concluded that spanlastics can be introduced as a promising nanotreatment modality for vitiligo.

Keywords

Spanlastics Bergamot oil Phototherapy Vitiligo 

Notes

Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest. The authors did not receive any specific grant from funding agencies in the public, commercial, or not-for profit sectors.

Ethical approval

All institutional and national guidelines for the use and care of laboratory animals were followed. All clinical procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki declaration of 1975, as revised in 2000 (5). Informed consent was obtained from all patients for being included in the study.

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Copyright information

© Controlled Release Society 2019

Authors and Affiliations

  1. 1.Department of Pharmaceutics and Industrial Pharmacy, Faculty of PharmacyAin Shams UniversityCairoEgypt
  2. 2.Dermatology and Laser Dermatology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced SciencesCairo UniversityCairoEgypt
  3. 3.Pharmaceutical Technology Unit, Department of Medical Applications of Laser, National Institute of Laser Enhanced SciencesCairo UniversityCairoEgypt

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