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Drug Delivery and Translational Research

, Volume 9, Issue 5, pp 968–979 | Cite as

Mesoporous silica nanoparticles, a safe option for silymarin delivery: preparation, characterization, and in vivo evaluation

  • Sarah S. Nasr
  • Maha M. A. Nasra
  • Heba A. HazzahEmail author
  • Ossama Y. Abdallah
Original Article
  • 148 Downloads

Abstract

The present work aimed to prepare silymarin-loaded mesoporous silica nanoparticles (MSNs) and to assess the system’s dissolution enhancement ability on the pharmacodynamic performance of silymarin as a hepatoprotective agent. For this purpose, a soft-templating technique was used to prepare silymarin-loaded MSNs. The loaded MSNs were further characterized for their particle size, zeta potential, surface properties, and in vitro drug dissolution testing. In addition, differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) were also carried out. DSC and specific surface area data confirmed deposition of silymarin in an amorphous state in MSNs’ pores. In vitro drug dissolution testing displayed enhanced dissolution rate of silymarin upon loading on MSNs compared with the free drug. Paracetamol-induced rat model of liver injury was used for the in vivo study. Plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), total proteins, liver homogenate content of thiobarbituric acid reactive species (TBARS), or lactate dehydrogenase (LDH) were assessed for all animal groups, treated and control ones. Based on parameters indicative of liver function, our results showed that the oral use of silymarin loaded onto MSNs at a dose of 250 mg/kg is significantly superior to free silymarin. Moreover, prolonged administration of the formulation had no evident toxicity on rats.

Keywords

Mesoporous silica Nanoparticles Toxicity Silymarin Liver function 

Notes

Acknowledgments

The authors would like to express their gratitude to the Institute of Post Graduate Studies and Research, the dean Prof. Mokhtar Youssef, and Dr. Alaa Fathy Ibrahim for their assistance with the preliminary in vivo experiments. They would also like to extend their sincere appreciation to Prof. Hanan el Goweli, Department of Pharmacology, Faculty of Pharmacy, Alexandria University, for her valuable assistance with the in vivo experiment.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Controlled Release Society 2019

Authors and Affiliations

  1. 1.Department of Pharmaceutics, Faculty of PharmacyAlexandria UniversityAlexandriaEgypt
  2. 2.Department of Pharmaceutics, Faculty of Pharmacy and Drug ManufacturingPharos University in AlexandriaAlexandriaEgypt

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