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Drug Delivery and Translational Research

, Volume 9, Issue 5, pp 920–934 | Cite as

Collagen biomaterial for the treatment of myocardial infarction: an update on cardiac tissue engineering and myocardial regeneration

  • Wei-qiang Wu
  • Song Peng
  • Zhi-yuan SongEmail author
  • Shu LinEmail author
Review Article
  • 199 Downloads

Abstract

Myocardial infarction (MI) remains one of the leading cause of mortality over the world. However, current treatments are more palliative than curative, which only stall the progression of the disease, but not reverse the disease. While stem cells or bioactive molecules therapy is promising, the limited survival and engraftment of bioactive agent due to a hostile environment is a bottleneck for MI treatment. In order to maximize the utility of stem cells and bioactive molecules for myocardial repair and regeneration, various types of biomaterials have been developed. Among them, collagen-based biomaterial is widely utilized for cardiac tissue engineering and regeneration due to its optimal physical and chemical properties. In this review, we summarize the properties of collagen-based biomaterial. Then, we discuss collagen-based biomaterial currently being applied to treat MI alone, or together with stem cells and/or bioactive molecules. Finally, the delivery system of collagen-based biomaterial will also be discussed.

Keywords

Myocardial infarction Collagen Biomaterials Stem cells Delivery systems 

Notes

Funding

This work was supported by the National Natural Science Foundation of China (Nos. 81670402 and 81570395).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Controlled Release Society 2019

Authors and Affiliations

  1. 1.Department of Cardiology, Southwest HospitalThird Military Medical University (Army Medical University)ChongqingChina
  2. 2.School of MedicineUniversity of Wollongong and Illawarra Health and Medical Research InstituteKeiravilleAustralia

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